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Τίτλος: Robotic device for transcranial focussed ultrasound applications in small animal models
Συγγραφείς: Antoniou, Anastasia 
Giannakou, Marinos 
Georgiou, Elena 
Kleopa, Kleopas A. 
Damianou, Christakis A. 
Major Field of Science: Engineering and Technology
Field Category: Electrical Engineering - Electronic Engineering - Information Engineering
Λέξεις-κλειδιά: robotic device;transcranial;BBB disruption;focussed ultrasound;mice;MRI compatible
Ημερομηνία Έκδοσης: Δεκ-2022
Πηγή: Intenational Journal of Medical Rodotics and Computer Assisted Surgery, 2022
Περιοδικό: Intenational Journal of Medical Rodotics and Computer Assisted Surgery 
Περίληψη: Abstract Background: Focussed Ultrasound (FUS) combined with microbubbles (MBs) was proven a promising modality for non‐invasive blood brain barrier disruption (BBBD). Herein, two devices for FUS‐mediated BBBD in rodents are presented. Methods: A two‐axes robotic device was manufactured for navigating a single element FUS transducer of 1 MHz relative to the brain of rodents. A second more compact device featuring a single motorized vertical axis was also developed. Their performance was assessed in terms of motion accuracy, MRI compatibility and trans‐skull BBBD in wild type mice using MBs in synergy with pulsed FUS. Results: Successful BBBD was evidenced by the Evans Blue dye method, as well as by Fibronectin and Fibrinogen immunostaining. BBB permeability was enhanced when the applied acoustic intensity was increased. Conclusions: The proposed devices constitute a cost‐effective and ergonomic solution for FUS‐mediated BBBD in small animal models. Further experimentation is needed to examine the repeatability of results and optimise the therapeutic protocol.
Description: Funding information Research and Innovation Foundation of Cyprus, Grant/Award Number: SOUNDPET (INTEGRATED/0918/0008); Piccolo Grande Guerriero ‐ Associazione Malattia PMLD, Grant/Award Number: 2020‐22 Grant
URI: https://hdl.handle.net/20.500.14279/28740
ISSN: 1478596X
DOI: 10.1002/rcs.2447
Rights: © The Authors
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation: Cyprus University of Technology 
Medsonic Ltd 
The Cyprus Institute of Neurology and Genetics 
Publication Type: Peer Reviewed
Εμφανίζεται στις συλλογές:Άρθρα/Articles

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