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Πεδίο DCΤιμήΓλώσσα
dc.contributor.authorAntoniou, Anastasia-
dc.contributor.authorGiannakou, Marinos-
dc.contributor.authorGeorgiou, Elena-
dc.contributor.authorKleopa, Kleopas A.-
dc.contributor.authorDamianou, Christakis A.-
dc.date.accessioned2023-03-21T12:54:31Z-
dc.date.available2023-03-21T12:54:31Z-
dc.date.issued2022-12-
dc.identifier.citationIntenational Journal of Medical Rodotics and Computer Assisted Surgery, 2022en_US
dc.identifier.issn1478596X-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/28740-
dc.descriptionFunding information Research and Innovation Foundation of Cyprus, Grant/Award Number: SOUNDPET (INTEGRATED/0918/0008); Piccolo Grande Guerriero ‐ Associazione Malattia PMLD, Grant/Award Number: 2020‐22 Granten_US
dc.description.abstractAbstract Background: Focussed Ultrasound (FUS) combined with microbubbles (MBs) was proven a promising modality for non‐invasive blood brain barrier disruption (BBBD). Herein, two devices for FUS‐mediated BBBD in rodents are presented. Methods: A two‐axes robotic device was manufactured for navigating a single element FUS transducer of 1 MHz relative to the brain of rodents. A second more compact device featuring a single motorized vertical axis was also developed. Their performance was assessed in terms of motion accuracy, MRI compatibility and trans‐skull BBBD in wild type mice using MBs in synergy with pulsed FUS. Results: Successful BBBD was evidenced by the Evans Blue dye method, as well as by Fibronectin and Fibrinogen immunostaining. BBB permeability was enhanced when the applied acoustic intensity was increased. Conclusions: The proposed devices constitute a cost‐effective and ergonomic solution for FUS‐mediated BBBD in small animal models. Further experimentation is needed to examine the repeatability of results and optimise the therapeutic protocol.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofIntenational Journal of Medical Rodotics and Computer Assisted Surgeryen_US
dc.rights© The Authorsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectrobotic deviceen_US
dc.subjecttranscranialen_US
dc.subjectBBB disruptionen_US
dc.subjectfocussed ultrasounden_US
dc.subjectmiceen_US
dc.subjectMRI compatibleen_US
dc.titleRobotic device for transcranial focussed ultrasound applications in small animal modelsen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationMedsonic Ltden_US
dc.collaborationThe Cyprus Institute of Neurology and Geneticsen_US
dc.subject.categoryElectrical Engineering - Electronic Engineering - Information Engineeringen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldEngineering and Technologyen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1002/rcs.2447en_US
cut.common.academicyear2022-2023en_US
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.author.deptDepartment of Electrical Engineering, Computer Engineering and Informatics-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0003-0424-2851-
crisitem.author.parentorgFaculty of Engineering and Technology-
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