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https://hdl.handle.net/20.500.14279/28740
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Antoniou, Anastasia | - |
dc.contributor.author | Giannakou, Marinos | - |
dc.contributor.author | Georgiou, Elena | - |
dc.contributor.author | Kleopa, Kleopas A. | - |
dc.contributor.author | Damianou, Christakis A. | - |
dc.date.accessioned | 2023-03-21T12:54:31Z | - |
dc.date.available | 2023-03-21T12:54:31Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.citation | Intenational Journal of Medical Rodotics and Computer Assisted Surgery, 2022 | en_US |
dc.identifier.issn | 1478596X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/28740 | - |
dc.description | Funding information Research and Innovation Foundation of Cyprus, Grant/Award Number: SOUNDPET (INTEGRATED/0918/0008); Piccolo Grande Guerriero ‐ Associazione Malattia PMLD, Grant/Award Number: 2020‐22 Grant | en_US |
dc.description.abstract | Abstract Background: Focussed Ultrasound (FUS) combined with microbubbles (MBs) was proven a promising modality for non‐invasive blood brain barrier disruption (BBBD). Herein, two devices for FUS‐mediated BBBD in rodents are presented. Methods: A two‐axes robotic device was manufactured for navigating a single element FUS transducer of 1 MHz relative to the brain of rodents. A second more compact device featuring a single motorized vertical axis was also developed. Their performance was assessed in terms of motion accuracy, MRI compatibility and trans‐skull BBBD in wild type mice using MBs in synergy with pulsed FUS. Results: Successful BBBD was evidenced by the Evans Blue dye method, as well as by Fibronectin and Fibrinogen immunostaining. BBB permeability was enhanced when the applied acoustic intensity was increased. Conclusions: The proposed devices constitute a cost‐effective and ergonomic solution for FUS‐mediated BBBD in small animal models. Further experimentation is needed to examine the repeatability of results and optimise the therapeutic protocol. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Intenational Journal of Medical Rodotics and Computer Assisted Surgery | en_US |
dc.rights | © The Authors | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | robotic device | en_US |
dc.subject | transcranial | en_US |
dc.subject | BBB disruption | en_US |
dc.subject | focussed ultrasound | en_US |
dc.subject | mice | en_US |
dc.subject | MRI compatible | en_US |
dc.title | Robotic device for transcranial focussed ultrasound applications in small animal models | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | Medsonic Ltd | en_US |
dc.collaboration | The Cyprus Institute of Neurology and Genetics | en_US |
dc.subject.category | Electrical Engineering - Electronic Engineering - Information Engineering | en_US |
dc.journals | Open Access | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Engineering and Technology | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1002/rcs.2447 | en_US |
cut.common.academicyear | 2022-2023 | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.author.dept | Department of Electrical Engineering, Computer Engineering and Informatics | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.orcid | 0000-0003-0424-2851 | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
Αρχεία σε αυτό το τεκμήριο:
Αρχείο | Περιγραφή | Μέγεθος | Μορφότυπος | |
---|---|---|---|---|
Robotic device_Christakis Damianou.pdf | Open Access | 892.27 kB | Adobe PDF | Δείτε/ Ανοίξτε |
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