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Title: RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
Authors: Brady, Marian C. 
Ali, Myzoon 
VandenBerg, Kathryn 
Williams, Linda J. 
Williams, Louise R. 
Abo, Masahiro 
Becker, Frank 
Bowen, Audrey 
Brandenburg, Caitlin 
Breitenstein, Caterina 
Bruehl, Stefanie 
Copland, David A. 
Cranfill, Tamara B. 
Di Pietro-Bachmann, Marie 
Enderby, Pamela 
Fillingham, Joanne 
Galli, Federica Lucia 
Gandolfi, Marialuisa 
Glize, Bertrand 
Godecke, Erin 
Hawkins, Neil 
Hilari, Katerina 
Hinckley, Jacqueline 
Horton, Simon 
Howard, David 
Jaecks, Petra 
Jefferies, Elizabeth 
Jesus, Luis M. T. 
Kambanaros, Maria 
Kang, Eun Kyoung 
Khedr, Eman M. 
Kong, Anthony Pak-Hin 
Kukkonen, Tarja 
Laganaro, Marina 
Ralph, Matthew A. Lambon 
Laska, Ann Charlotte 
Leemann, Beatrice 
Leff, Alexander P. 
Lima, Roxele R. 
Lorenz, Antje 
Whinney, Brian Mac 
Marshall, Rebecca Shisler 
Mattioli, Flavia 
Mavis, İlknur 
Meinzer, Marcus 
Nilipour, Reza 
Noe, Enrique 
Papathanasiou, Ilias 
Patricio, Brigida F. 
Martins, Isabel Pavao 
Price, Cathy 
Jakovac, Tatjana Prizl 
Rochon, Elizabeth 
Rose, Miranda L. 
Rosso, Charlotte 
Rubi-Fessen, Ilona 
Ruiter, Marina B. 
Snell, Claerwen 
Stahl, Benjamin 
Szaflarski, Jerzy P. 
Thomas, Shirley A. 
Van de Sandt-Koenderman, Mieke 
Van der Meulen, Ineke 
Visch-Brink, Evy 
Worrall, Linda 
Wright, Heather Harris 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: Stroke;Aphasia;Complex intervention;IPD;Meta-analysis
Issue Date: 2020
Source: Aphasiology, 2020, vol. 34, no. Issue 2, pp. 137-157
Volume: 34
Issue: 2
Start page: 137
End page: 157
Journal: Aphasiology 
Abstract: Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)
ISSN: 1464-5041
Rights: © Taylor & Francis
Type: Article
Affiliation : University of Queensland 
Glasgow Caledonian University 
The University of Edinburgh 
Jikei University 
University of Oslo 
Sunnaas Rehabilitation Hospital 
The University of Manchester 
University of Queensland 
University of Munster 
Eastern Kentucky University 
University of Geneva 
University of Sheffield 
NHS Improvement 
Marche Polytechnic University 
University of Verona 
University of Bordeaux 
Centre Hospitalier Universitaire de Bordeaux 
Edith Cowan University 
University of Glasgow 
City, University of London 
Nova Southeastern University 
University of East Anglia 
Newcastle University 
University of Bielefeld 
University of York 
Universidade de Aveiro 
Cyprus University of Technology 
Kangwon National University 
Assiut University 
University of Central Florida 
Tampere University 
University of Cambridge 
Karolinska Institutet 
University College London 
Educational Association Bom Jesus 
Humboldt-Universitat zu Berlin 
Carnegie Mellon University 
University of Georgia 
Hospital Spedali Civili Brescia 
Anadolu University 
University of Queensland 
University of Social Welfare and Rehabilitation Sciences 
Hospitales Vithas 
Seoul National University 
Western Greece University of Applied Sciences 
Polytechnic Institute of Porto 
University of Lisbon 
University of Zagreb 
University of Toronto 
La Trobe University 
Sorbonne Universités 
University of Cologne 
Radboud University Nijmegen 
Warrington Hospital 
Charité-Universitätsmedizin Berlin 
University of Alabama at Birmingham 
University of Nottingham 
Rijndam Rehabilitation 
Erasmus University Rotterdam 
East Carolina University 
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