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https://hdl.handle.net/20.500.14279/10971
Title: | Bioconversion of alkaloids to high-value chemicals: Comparative analysis of newly isolated lupanine degrading strains | Authors: | Parmaki, Stella Vyrides, Ioannis Vasquez Christodoulou, Marlen Hartman, Viki Zacharia, Irene Hadjiadamou, Ioanna Barbeitos, Catarina B.M Ferreira, Frederico C. Afonso, Carlos A.M. Drouza, Chryssoula Koutinas, Michalis |
Major Field of Science: | Natural Sciences | Field Category: | Chemical Sciences | Keywords: | Bioconversion;Biodegradation;Lupanine;Quinolizidine alkaloids;Toxicity assessment | Issue Date: | Feb-2018 | Source: | Chemosphere, 2018, vol. 193, pp. 50-59 | Volume: | 193 | Start page: | 50 | End page: | 59 | Journal: | Chemosphere | Abstract: | This work explores the potential for development of a lupanine valorization process evaluating different isolated microorganisms for their capacity to metabolize the alkaloid. Ecotoxicological assessment demonstrated that lupanine is toxic for Vibrio fischeri and Daphnia magna exhibiting EC50 values of 89 mg L−1 and 47 mg L−1 respectively, while acting both as growth inhibitor for a monocotyledonous and as promoter for a dicotyledonous plant. Among the eight aerobic and anaerobic strains isolated and identified Rhodococcus rhodochrous LPK211 achieved 81% removal for 1.5 g L−1 lupanine, while no end-products were detected by NMR constituting a promising microorganism for lupanine biodegradation. Moreover, Rhodococcus ruber LPK111 and Rhodococcus sp. LPK311 exhibited 66% and 71% of removal respectively, including potential formation of lupanine N-oxide. Pseudomonas putida LPK411 reached 80% of lupanine removal and generated three fermentation products potentially comprising 17-oxolupanine and lupanine derivatives with open ring structures enabling the development of alkaloid valorization processes. | URI: | https://hdl.handle.net/20.500.14279/10971 | ISSN: | 00456535 | DOI: | 10.1016/j.chemosphere.2017.10.165 | Rights: | © Elsevier | Type: | Article | Affiliation : | Cyprus University of Technology University of Cyprus University of Lisbon |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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