AM-FM texture image analysis in multiple sclerosis brain white matter lesions
File(s)
Journal
Mediterranean Conference on Medical and Biological Engineering and Computing
Date Issued
May 2010
Abstract
In this study we investigate the use of multiscale Amplitude Modulation-Frequency Modulation (AM-FM) methods for analyzing brain white matter lesions that are associated with multiple sclerosis MRI lesions imaged at 0 and 6-12 months. We use the instantaneous amplitude (IA) and the instantaneous frequency (IF) to assess disease progression. The IA and the IF were calculated in transverse sections of T2- weighted magnetic resonance (MR) images acquired from 38 symptomatic untreated subjects between the first and the second examination scan. The findings suggest that the high-, medium-, and low- frequency scale instantaneous amplitude and frequency can be used to differentiate between normal tissue and lesions at 0 and 6-12 months. Moreover, support vector machine (SVM) models gave satisfactory results for differentiating lesions at 0 months using the medium scale IA and IF components for expanded disability status scale (EDSS) <=2 and EDSS >2. Further work is needed with more subjects in validating the proposed AM-FM analysis. © 2010 International Federation for Medical and Biological Engineering.