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https://hdl.handle.net/20.500.14279/9888
Τίτλος: | Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Study | Συγγραφείς: | Liu, Xiaowen Hamnvik, Ole Petter Riksfjord Chamberland, John P. Petrou, Michael Gong, Huizhi Christophi, Costas A. Christiani, David C. Kales, Stefanos N. Mantzoros, Christos S. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Basic Medicine | Λέξεις-κλειδιά: | Insulin resistance;Metabolic syndrome;Obesity | Ημερομηνία Έκδοσης: | Ιου-2014 | Πηγή: | Metabolism, 2014, vol. 63, no. 6, pp. 773-782 | Volume: | 63 | Issue: | 6 | Start page: | 773 | End page: | 782 | Περιοδικό: | Metabolism | Περίληψη: | Objective To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. Research Design and Methods 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. Results In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r = 0.17, p <.0001) and HOMA-IR (r = 0.16, p = 0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. Conclusions We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults. | URI: | https://hdl.handle.net/20.500.14279/9888 | ISSN: | 00260495 | DOI: | 10.1016/j.metabol.2014.03.008 | Rights: | © Elsevier | Type: | Article | Affiliation: | Cyprus University of Technology Harvard University Boston VA Healthcare System |
Publication Type: | Peer Reviewed |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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