Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/9888
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Xiaowen | - |
dc.contributor.author | Hamnvik, Ole Petter Riksfjord | - |
dc.contributor.author | Chamberland, John P. | - |
dc.contributor.author | Petrou, Michael | - |
dc.contributor.author | Gong, Huizhi | - |
dc.contributor.author | Christophi, Costas A. | - |
dc.contributor.author | Christiani, David C. | - |
dc.contributor.author | Kales, Stefanos N. | - |
dc.contributor.author | Mantzoros, Christos S. | - |
dc.date.accessioned | 2017-02-23T12:48:33Z | - |
dc.date.available | 2017-02-23T12:48:33Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | Metabolism, 2014, vol. 63, no. 6, pp. 773-782 | en_US |
dc.identifier.issn | 00260495 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/9888 | - |
dc.description.abstract | Objective To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. Research Design and Methods 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. Results In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r = 0.17, p <.0001) and HOMA-IR (r = 0.16, p = 0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. Conclusions We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Metabolism | en_US |
dc.rights | © Elsevier | en_US |
dc.subject | Insulin resistance | en_US |
dc.subject | Metabolic syndrome | en_US |
dc.subject | Obesity | en_US |
dc.title | Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Study | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | Harvard University | en_US |
dc.collaboration | Boston VA Healthcare System | en_US |
dc.subject.category | Basic Medicine | en_US |
dc.journals | Subscription | en_US |
dc.country | Cyprus | en_US |
dc.country | United States | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1016/j.metabol.2014.03.008 | en_US |
dc.identifier.pmid | 24726813 | - |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 63 | en_US |
cut.common.academicyear | 2013-2014 | en_US |
dc.identifier.spage | 773 | en_US |
dc.identifier.epage | 782 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 0026-0495 | - |
crisitem.journal.publisher | Elsevier | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0003-0503-1538 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
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