Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/9888
DC FieldValueLanguage
dc.contributor.authorLiu, Xiaowen-
dc.contributor.authorHamnvik, Ole Petter Riksfjord-
dc.contributor.authorChamberland, John P.-
dc.contributor.authorPetrou, Michael-
dc.contributor.authorGong, Huizhi-
dc.contributor.authorChristophi, Costas A.-
dc.contributor.authorChristiani, David C.-
dc.contributor.authorKales, Stefanos N.-
dc.contributor.authorMantzoros, Christos S.-
dc.date.accessioned2017-02-23T12:48:33Z-
dc.date.available2017-02-23T12:48:33Z-
dc.date.issued2014-06-
dc.identifier.citationMetabolism, 2014, vol. 63, no. 6, pp. 773-782en_US
dc.identifier.issn00260495-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/9888-
dc.description.abstractObjective To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. Research Design and Methods 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. Results In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r = 0.17, p <.0001) and HOMA-IR (r = 0.16, p = 0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. Conclusions We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofMetabolismen_US
dc.rights© Elsevieren_US
dc.subjectInsulin resistanceen_US
dc.subjectMetabolic syndromeen_US
dc.subjectObesityen_US
dc.titleCirculating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Studyen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationHarvard Universityen_US
dc.collaborationBoston VA Healthcare Systemen_US
dc.subject.categoryBasic Medicineen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.metabol.2014.03.008en_US
dc.identifier.pmid24726813-
dc.relation.issue6en_US
dc.relation.volume63en_US
cut.common.academicyear2013-2014en_US
dc.identifier.spage773en_US
dc.identifier.epage782en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn0026-0495-
crisitem.journal.publisherElsevier-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0003-0503-1538-
crisitem.author.parentorgFaculty of Health Sciences-
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