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  4. Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization
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Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization

Journal
Applied Optics
Date Issued
May 20, 2015
Author(s)
Viphavakit, Charusluk  
Komodromos, Michael  
Themistos, Christos  
Mohammed, Waleed S.  
Kalli, Kyriacos  
Rahman, B. M. Azizur  
DOI
10.1364/AO.54.004881
10.1364/AO.54.004881
Abstract
A full-vectorial H-field formulation-based finite element approach is used to optimize a biosensor structure incorporating a horizontal slot waveguide. It is designed to detect DNA hybridization through the change of the effective index of the waveguide structure. The key parameters, such as normalized power confinement, power density, change in effective index, and sensitivity are presented by optimizing the device parameters of the slot waveguide. It is shown here that a 90.0 μm long compact Mach-Zehnder section can be designed with horizontal slot waveguide to detect DNA hybridization and for a ring resonator arrangement a sensitivity of 893.5 nm/RIU is obtained.
Subjects

DNA

DNA, Single-Stranded

Equipment design

Models theoretical

Oxides

Oxygen

Refractometry

Reproducibility of re...

Silicon

Silicon dioxide

Biosensing techniques...

Nucleic Acid Hybridiz...

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