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https://hdl.handle.net/20.500.14279/9165
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Makris, Konstantinos C. | - |
dc.contributor.author | Andrianou, Xanthi | - |
dc.contributor.author | Charisiadis, Pantelis | - |
dc.contributor.author | Burch, James Bradford | - |
dc.contributor.author | Seth, Ratanesh Kumar | - |
dc.contributor.author | Ioannou, Androniki | - |
dc.contributor.author | Picolos, Michael | - |
dc.contributor.author | Christophi, Costas A. | - |
dc.contributor.author | Chatterjee, Saurabh | - |
dc.contributor.other | Μακρής, Κωνσταντίνος | - |
dc.contributor.other | Ανδριανού, Ξάνθη | - |
dc.contributor.other | Χαρισιάδης, Παντελής | - |
dc.contributor.other | Χριστοφή, Κώστας | - |
dc.date.accessioned | 2017-01-20T07:08:44Z | - |
dc.date.available | 2017-01-20T07:08:44Z | - |
dc.date.issued | 2016-07-01 | - |
dc.identifier.citation | Environment International, 2016, vol. 92-93, pp. 486-493 | en_US |
dc.identifier.issn | 18736750 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/9165 | - |
dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder in the Western world, commonly diagnosed in the majority of obese patients with type 2 diabetes mellitus (T2DM). Metabolic disrupting chemicals with short half-lives, such as those of halogenated structure (trihalomethanes, THM) have been linked with hepatic insulin resistance phenomena in animal studies. However, human studies evaluating the role of THM exposure on liver pathogenesis and T2DM disease process are scarce. The objectives of this study were to: i) determine the association of urinary brominated THM (BrTHM) levels and T2DM disease status, and ii) investigate the association between urinary BrTHM levels and serum alanine aminotransferase (ALT) concentrations, often used as surrogate markers of NAFLD. A pilot case-control study was conducted in Nicosia, Cyprus (n = 95). Cases were physician-diagnosed T2DM patients and controls were healthy individuals. Liver enzymes, leptin and TNF-α were measured in sera, while urinary THM levels were measured using tandem mass spectrometry. Diabetics had higher levels of serum leptin, body mass index and ALT than the controls. Among all study participants those with serum ALT levels above the median (17 IU/L) had higher mean tribromomethane (TBM) concentrations compared to those with serum ALT below 17 IU/L. A significant increase in the odds of having above the median serum ALT levels [OR 6.38, 95% CI: 1.11, 42.84 (p = 0.044)] was observed for each unit increase in creatinine-unadjusted urinary TBM levels, along with BMI and past smoking, after adjusting for possible confounders, such as urinary creatinine, age, sex, and leptin; no other THM compound showed a significant association with serum ALT. Logistic regression models for T2DM using the urinary BrTHM as exposure variables did not reach the predetermined level of significance. The interplay between exposures to BrTHM and the initiation of key pathophysiological events relating to hepatic injury (ALT) and inflammation (leptin) was recognized via the use of selected biomarkers of effect. Our evidence that THM could act as hepatic toxins with a further initiation of diabetogenic effects call for additional studies to help us better understand the disease process of the two co-morbidities (NAFLD and T2DM). | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Environment International | en_US |
dc.rights | © Elsevier | en_US |
dc.subject | Brominated trihalomethanes | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Disinfection byproducts | en_US |
dc.subject | Fatty liver | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Non-alcoholic | en_US |
dc.subject | Obesity | en_US |
dc.title | Association between exposures to brominated trihalomethanes, hepatic injury and type II diabetes mellitus | en_US |
dc.type | Article | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | University of South Carolina | en_US |
dc.collaboration | Endocrinology Clinic | en_US |
dc.collaboration | Dorn Department of Veterans Affairs Medical Center | en_US |
dc.subject.category | Health Sciences | en_US |
dc.journals | Subscription | en_US |
dc.country | Cyprus | en_US |
dc.country | United States | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1016/j.envint.2016.04.012 | en_US |
dc.relation.volume | 92-93 | en_US |
cut.common.academicyear | 2015-2016 | en_US |
dc.identifier.spage | 486 | en_US |
dc.identifier.epage | 493 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 0160-4120 | - |
crisitem.journal.publisher | Elsevier | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0001-5251-8619 | - |
crisitem.author.orcid | 0000-0002-2906-5743 | - |
crisitem.author.orcid | 0000-0001-7260-192X | - |
crisitem.author.orcid | 0000-0003-0503-1538 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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