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https://hdl.handle.net/20.500.14279/8867| Τίτλος: | PK11195, a peripheral benzodiazepine receptor ligand, potentiates cytotoxic action on cholangiocarcinoma cell lines | Συγγραφείς: | Pericleous, S. Mathieson, W. Middleton, Nicos McKay, S. Biswas, A. Thomas, G. Spalding, D. Hutchins, R. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Health Sciences | Λέξεις-κλειδιά: | Cholangiocarcinoma;Chemotherapy | Ημερομηνία Έκδοσης: | 2011 | Πηγή: | HPB, 2011, vol. 13, supp. 2, pp. 30-31 | Volume: | 13 | Issue: | 2 | Start page: | 30 | End page: | 31 | Περιοδικό: | HPB | Περίληψη: | Cholangiocarcinoma (CC) is an uncommon disease with a dismal prognosis. Patients with surgically unresectable disease benefi t little from conventional anticancer therapies such as chemotherapy and radiotherapy. 1-(2-chlorophenylN-methylpropyl)-3-isoquinolinecarboxamide (PK11195) is a benzodiazepine receptor ligand which antagonizes Bcl-2 and Bcl-XL function thus preventing the inhibition of apoptosis. Our aim was to determine the effect of adding PK11195 in vitro to commercially available chemotherapy agents on cultured CC cell lines. | URI: | https://hdl.handle.net/20.500.14279/8867 | ISSN: | 1365182X | DOI: | 10.1111/j.1477-2574.2011.00308.x | Rights: | © International Hepato-Pancreato-Biliary Association | Type: | Article | Affiliation: | Imperial College London Royal London Hospital Cyprus University of Technology |
Publication Type: | Peer Reviewed |
| Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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