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Τίτλος: Infection probability score, APACHE II and KARNOFSKY scoring systems as predictors of bloodstream infection onset in hematology-oncology patients
Συγγραφείς: Elefsiniotis, Ioannis S. 
Apostolopoulou, Eleni A. 
Terzis, Konstantinos 
Raftopoulos, Vasilios 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Λέξεις-κλειδιά: Antibiotic agent;Acute granulocytic leukemia;Adolescent;Aged;APACHE;Bloodstream infection;Catheterization;Controlled study;Adult;Diagnostic value;Drug exposure;Female;Greece;Human;Infection Probability Score;Infection risk;Karnofsky Performance Status;Length of stay;Major clinical study;Male;Neutropenia;Prediction;Prognosis;Retrospective study;Scoring system;Sensitivity and specificity;Bacteremia;Blood disease;Fungemia;Hospitalization;Middle aged;Neutropenia
Ημερομηνία Έκδοσης: 26-Μαΐ-2010
Πηγή: BMC Infectious Diseases, 2010, vol. 10, no. 135, pp.1-8
Volume: 10
Issue: 135
Start page: 1
End page: 8
Περιοδικό: BMC Infectious Diseases 
Περίληψη: Background: Bloodstream Infections (BSIs) in neutropenic patients often cause considerable morbidity and mortality. Therefore, the surveillance and early identification of patients at high risk for developing BSIs might be useful for the development of preventive measures. The aim of the current study was to assess the predictive power of three scoring systems: Infection Probability Score (IPS), APACHE II and KARNOFSKY score for the onset of Bloodstream Infections in hematology-oncology patients.Methods: A total of 102 patients who were hospitalized for more than 48 hours in a hematology-oncology department in Athens, Greece between April 1stand October 31st2007 were included in the study. Data were collected by using an anonymous standardized recording form. Source materials included medical records, temperature charts, information from nursing and medical staff, and results on microbiological testing. Patients were followed daily until hospital discharge or death.Results: Among the 102 patients, Bloodstream Infections occurred in 17 (16.6%) patients. The incidence density of Bloodstream Infections was 7.74 per 1,000 patient-days or 21.99 per 1,000 patient-days at risk. The patients who developed a Bloodstream Infection were mainly females (p = 0.004), with twofold time mean length of hospital stay (p <, 0.001), with fourfold time mean length of neutropenia (p <, 0.001), with neutropenia <, 500 (p <, 0.001), suffered mainly from acute myeloid leukemia (p <, 0.001), had been exposed to antibiotics (p = 0.045) and chemotherapy (p = 0.023), had a surgery (p = 0.048) and a Hickman catheter (p = 0.025) as compared to the patients without Bloodstream Infection. The best cut-off value of IPS for the prediction of a Bloodstream Infection was 10 with a sensitivity of 75% and specificity of 70.9%. Conclusion: Between the three different prognostic scoring systems, Infection Probability Score had the best sensitivity in predicting Bloodstream Infections. 2010 Apostolopoulou et al, licensee BioMed Central Ltd.
URI: https://hdl.handle.net/20.500.14279/3752
ISSN: 14712334
DOI: 10.1186/1471-2334-10-135
Rights: © BioMed Central
Type: Article
Affiliation: National and Kapodistrian University of Athens 
Cyprus University of Technology 
Halkida General Hospital 
Mediterranean Research Centre for Public Health and Quality of Care 
Publication Type: Peer Reviewed
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