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https://hdl.handle.net/20.500.14279/3752
Τίτλος: | Infection probability score, APACHE II and KARNOFSKY scoring systems as predictors of bloodstream infection onset in hematology-oncology patients | Συγγραφείς: | Elefsiniotis, Ioannis S. Apostolopoulou, Eleni A. Terzis, Konstantinos Raftopoulos, Vasilios |
Major Field of Science: | Medical and Health Sciences | Field Category: | Health Sciences | Λέξεις-κλειδιά: | Antibiotic agent;Acute granulocytic leukemia;Adolescent;Aged;APACHE;Bloodstream infection;Catheterization;Controlled study;Adult;Diagnostic value;Drug exposure;Female;Greece;Human;Infection Probability Score;Infection risk;Karnofsky Performance Status;Length of stay;Major clinical study;Male;Neutropenia;Prediction;Prognosis;Retrospective study;Scoring system;Sensitivity and specificity;Bacteremia;Blood disease;Fungemia;Hospitalization;Middle aged;Neutropenia | Ημερομηνία Έκδοσης: | 26-Μαΐ-2010 | Πηγή: | BMC Infectious Diseases, 2010, vol. 10, no. 135, pp.1-8 | Volume: | 10 | Issue: | 135 | Start page: | 1 | End page: | 8 | Περιοδικό: | BMC Infectious Diseases | Περίληψη: | Background: Bloodstream Infections (BSIs) in neutropenic patients often cause considerable morbidity and mortality. Therefore, the surveillance and early identification of patients at high risk for developing BSIs might be useful for the development of preventive measures. The aim of the current study was to assess the predictive power of three scoring systems: Infection Probability Score (IPS), APACHE II and KARNOFSKY score for the onset of Bloodstream Infections in hematology-oncology patients.Methods: A total of 102 patients who were hospitalized for more than 48 hours in a hematology-oncology department in Athens, Greece between April 1stand October 31st2007 were included in the study. Data were collected by using an anonymous standardized recording form. Source materials included medical records, temperature charts, information from nursing and medical staff, and results on microbiological testing. Patients were followed daily until hospital discharge or death.Results: Among the 102 patients, Bloodstream Infections occurred in 17 (16.6%) patients. The incidence density of Bloodstream Infections was 7.74 per 1,000 patient-days or 21.99 per 1,000 patient-days at risk. The patients who developed a Bloodstream Infection were mainly females (p = 0.004), with twofold time mean length of hospital stay (p <, 0.001), with fourfold time mean length of neutropenia (p <, 0.001), with neutropenia <, 500 (p <, 0.001), suffered mainly from acute myeloid leukemia (p <, 0.001), had been exposed to antibiotics (p = 0.045) and chemotherapy (p = 0.023), had a surgery (p = 0.048) and a Hickman catheter (p = 0.025) as compared to the patients without Bloodstream Infection. The best cut-off value of IPS for the prediction of a Bloodstream Infection was 10 with a sensitivity of 75% and specificity of 70.9%. Conclusion: Between the three different prognostic scoring systems, Infection Probability Score had the best sensitivity in predicting Bloodstream Infections. 2010 Apostolopoulou et al, licensee BioMed Central Ltd. | URI: | https://hdl.handle.net/20.500.14279/3752 | ISSN: | 14712334 | DOI: | 10.1186/1471-2334-10-135 | Rights: | © BioMed Central | Type: | Article | Affiliation: | National and Kapodistrian University of Athens Cyprus University of Technology Halkida General Hospital Mediterranean Research Centre for Public Health and Quality of Care |
Publication Type: | Peer Reviewed |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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