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https://hdl.handle.net/20.500.14279/3672
Πεδίο DC | Τιμή | Γλώσσα |
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dc.contributor.author | Holmes, Michael Vaclav | - |
dc.contributor.author | Dale, Caroline E. | - |
dc.contributor.author | Zuccolo, Luisa | - |
dc.contributor.author | Silverwood, Richard J. | - |
dc.contributor.author | Guo, Yiran | - |
dc.contributor.author | Ye, Zheng | - |
dc.contributor.author | Prieto-Merino, David | - |
dc.contributor.author | Dehghan, Abbas Jan | - |
dc.contributor.author | Trompet, Stella | - |
dc.contributor.author | Wong, Andrew | - |
dc.contributor.author | Cavadino, Alana | - |
dc.contributor.author | Hakonarson, Hakon H. | - |
dc.contributor.author | Watkins, Hugh C. | - |
dc.contributor.author | Schreiner, Pamela J. | - |
dc.contributor.author | Ellison, Robert Curtis | - |
dc.contributor.author | Voevoda, Mikhail Ivanovich | - |
dc.contributor.author | Li, Yun R. | - |
dc.contributor.author | Redline, Susan S. | - |
dc.contributor.author | Spiering, Wilko | - |
dc.contributor.author | Nordestgaard, Borge Grpnne | - |
dc.contributor.author | Bobak, Martin | - |
dc.contributor.author | Meade, Tom W. | - |
dc.contributor.author | Ferro, Jose Manuel M | - |
dc.contributor.author | Padmanabhan, Sandosh | - |
dc.contributor.author | Psaty, Bruce M. | - |
dc.contributor.author | Jorgenson, Eric M. | - |
dc.contributor.author | Rotter, Jerome I. | - |
dc.contributor.author | Lawlor, Debbie A. | - |
dc.contributor.author | Hardy, Rebecca J. | - |
dc.contributor.author | Li, Shanshan | - |
dc.contributor.author | Yesupriya, Ajay | - |
dc.contributor.author | Hamsten, Anders | - |
dc.contributor.author | Hubacek, Jaroslav Alois | - |
dc.contributor.author | Dowling, Nicole F. | - |
dc.contributor.author | Shah, Tina S. | - |
dc.contributor.author | Reiner, Alexander Paul | - |
dc.contributor.author | Johnson, Andrew D. | - |
dc.contributor.author | Wilson, James G. | - |
dc.contributor.author | Langenberg, Claudia | - |
dc.contributor.author | Morris, Richard W. | - |
dc.contributor.author | Engmann, Jorgen E L | - |
dc.contributor.author | Folkersen, Lasse | - |
dc.contributor.author | Peasey, Anne E. | - |
dc.contributor.author | Vikhireva, Olga V. | - |
dc.contributor.author | Borinskaya, Svetlana A. | - |
dc.contributor.author | Mukamal, Kenneth Jay | - |
dc.contributor.author | Finan, Chris I. | - |
dc.contributor.author | Whittaker, John C. | - |
dc.contributor.author | Casas, Juan Pablo | - |
dc.contributor.author | Sundstrom, Johan | - |
dc.contributor.author | Farrall, Martin J. | - |
dc.contributor.author | Keating, Brendan J. | - |
dc.contributor.author | Swerdlow, Daniel I. | - |
dc.contributor.author | Lanktree, Matthew B. | - |
dc.contributor.author | Sluijs, Ivonne | - |
dc.contributor.author | Scott, Robert Alastair Howie | - |
dc.contributor.author | Hofman, Albert | - |
dc.contributor.author | Paulos-Pinheiro, Sofia | - |
dc.contributor.author | Rayaprolu, Sruti | - |
dc.contributor.author | Palmer, Tom M. | - |
dc.contributor.author | Shah, Sonia H. | - |
dc.contributor.author | Ricceri, F. | - |
dc.contributor.author | Spring, Bonnie J. | - |
dc.contributor.author | Humphries, Steve Eric | - |
dc.contributor.author | Talmud, Philippa J. | - |
dc.contributor.author | Patel, Sanjay Rajnikant | - |
dc.contributor.author | Hypponen, Elina | - |
dc.contributor.author | Dominiczak, Anna F D | - |
dc.contributor.author | Power, Chris | - |
dc.contributor.author | Panayiotou, Andrie | - |
dc.contributor.author | Ross, Owen A. | - |
dc.contributor.author | Flicker, Leon A. | - |
dc.contributor.author | Sattar, Naveed A. | - |
dc.contributor.author | Kumari, Meena | - |
dc.contributor.author | Nicolaides, Andrew N. | - |
dc.contributor.author | Beulens, Joline WJ J | - |
dc.contributor.author | Onland-Moret, N. Charlotte | - |
dc.contributor.author | Gamble, Dale M. | - |
dc.contributor.author | Van Der Harst, Pim | - |
dc.contributor.author | Melander, Olle | - |
dc.contributor.author | Marmot, Michael Gideon Ideon | - |
dc.contributor.author | Verweij, Niek | - |
dc.contributor.author | Smith, George Davey W | - |
dc.contributor.author | Marques-Vidal, Pedro | - |
dc.contributor.author | Doevendans, Pieter A F M | - |
dc.contributor.author | Leon, David A. | - |
dc.contributor.author | Malyutina, Sofia K. | - |
dc.contributor.author | Fornage, Myriam | - |
dc.contributor.author | Franco, Oscar H. | - |
dc.contributor.author | Price, Jackie F. | - |
dc.contributor.author | Van Bockxmeer, Frank M. | - |
dc.contributor.author | Klungel, Olaf H H | - |
dc.contributor.author | Boeing, Heiner | - |
dc.contributor.author | Leusink, Maarten | - |
dc.contributor.author | Cooper, Jackie A. | - |
dc.contributor.author | Palmen, Jutta A. | - |
dc.contributor.author | Buxbaum, Sarah G. | - |
dc.contributor.author | Almeida, Osvaldo P De Campos | - |
dc.contributor.author | Norman, Paul E. | - |
dc.contributor.author | Cramer, Maarten Jan M | - |
dc.contributor.author | Hankey, Graeme J. | - |
dc.contributor.author | Linneberg, Allan | - |
dc.contributor.author | Kubinova, Ruzena | - |
dc.contributor.author | Pajak, Andrzej | - |
dc.contributor.author | Pikhart, Hynek | - |
dc.contributor.author | Lannfelt, Lars | - |
dc.contributor.author | Tamosiunas, Abdonas | - |
dc.contributor.author | Eriksson, Per Olof | - |
dc.contributor.author | Wareham, Nicholas J. | - |
dc.contributor.author | Khaw, Kay Tee T | - |
dc.contributor.author | Boerwinkle, Eric Eric | - |
dc.contributor.author | Hofker, Marten H. | - |
dc.contributor.author | Ikram, Mohammad Arfan | - |
dc.contributor.author | Ebrahim, Shah B J | - |
dc.contributor.author | Bergmann, Manuela M. | - |
dc.contributor.author | De Jong, Pim A. | - |
dc.contributor.author | Sacerdote, Carlotta | - |
dc.contributor.author | Wannamethee, Sasiwarang Goya Oya | - |
dc.contributor.author | Whincup, Peter H. | - |
dc.contributor.author | Adamkova, Vera | - |
dc.contributor.author | Lange, Leslie | - |
dc.contributor.author | Kooperberg, Charles L. | - |
dc.contributor.author | Tolstrup, Janne Schurmann Churmann | - |
dc.contributor.author | Maitland-van Der Zee, Anke Hilse | - |
dc.contributor.author | Ford, Ian | - |
dc.contributor.author | Husemoen, Lise Lotte Nystrup | - |
dc.contributor.author | Leach, Irene Mateo | - |
dc.contributor.author | LaCroix, Andrea Z. | - |
dc.contributor.author | Dai, James Y. | - |
dc.contributor.author | Dudbridge, Frank | - |
dc.contributor.author | Drogan, Dagmar | - |
dc.contributor.author | Uitterlinden, Andre Gerardus | - |
dc.contributor.author | Cupples, L. Adrienne | - |
dc.contributor.author | Kuh, Diana | - |
dc.contributor.author | Verschuren, Wm Monique Monique | - |
dc.contributor.author | Vicente, Astrid Moura | - |
dc.contributor.author | Skaaby, Tea | - |
dc.contributor.author | Rimm, Eric B. | - |
dc.contributor.author | Jukema, Johan Wouter Outer | - |
dc.contributor.author | Weikert, Cornelia | - |
dc.contributor.author | Tsai, Michael | - |
dc.contributor.author | Kuchenbaecker, Karoline B. | - |
dc.contributor.author | De Bakker, Paul IW W | - |
dc.contributor.author | Coresh, Josef | - |
dc.contributor.author | Tjonneland, Anne Marie | - |
dc.contributor.author | Sharp, Stephen John | - |
dc.contributor.author | Siscovick, David S. | - |
dc.contributor.author | Gaunt, Tom R. | - |
dc.contributor.author | Kivimaki, Mika | - |
dc.contributor.author | Asselbergs, Folkert W. | - |
dc.contributor.author | McLachlan, Stela | - |
dc.contributor.author | Hamidovic, Ajna | - |
dc.contributor.author | Hoogeveen, Ron Cornelis A J M | - |
dc.contributor.author | Meschia, James F. | - |
dc.date.accessioned | 2015-04-20T07:24:02Z | - |
dc.date.accessioned | 2015-12-08T11:09:57Z | - |
dc.date.available | 2015-04-20T07:24:02Z | - |
dc.date.available | 2015-12-08T11:09:57Z | - |
dc.date.issued | 2014-07-10 | - |
dc.identifier.citation | BMJ, 2014, vol. 349 | en_US |
dc.identifier.issn | 17561833 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/3672 | - |
dc.description.abstract | Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. Results: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m2). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). Conclusions: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | BMJ open | en_US |
dc.rights | © Publishing Group | en_US |
dc.subject | Alcohol abstinence | en_US |
dc.subject | Alcohol consumption | en_US |
dc.subject | Alcohol dehydrogenase 1B gene | en_US |
dc.title | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | en_US |
dc.type | Article | en_US |
dc.collaboration | University College London | en_US |
dc.collaboration | University of Pennsylvania | en_US |
dc.collaboration | London School of Hygiene and Tropical Medicine | en_US |
dc.collaboration | University of Bristol | en_US |
dc.collaboration | Childrens Hospital of Philadelphia | en_US |
dc.collaboration | Beishan Industrial Zone | en_US |
dc.collaboration | Addenbrooke's Hospital | en_US |
dc.collaboration | Erasmus University Rotterdam | en_US |
dc.collaboration | Leiden University | en_US |
dc.collaboration | UCL | en_US |
dc.collaboration | UCL Institute of Child Health | en_US |
dc.collaboration | German Institute of Human Nutrition Potsdam-Rehbrücke | en_US |
dc.collaboration | University of Glasgow | en_US |
dc.collaboration | Office of Public Health Genomics | en_US |
dc.collaboration | Utrecht Institute for Pharmaceutical Sciences | en_US |
dc.collaboration | Uppsala University | en_US |
dc.collaboration | Institute for Clinical and Experimental Medicine | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | Russian Academy of Sciences | en_US |
dc.collaboration | UCL Genetics Institute | en_US |
dc.collaboration | University of Cambridge | en_US |
dc.collaboration | Karolinska Institutet | en_US |
dc.collaboration | Lund University | en_US |
dc.collaboration | San Giovanni Battista Hospital and Center for Cancer Prevention | en_US |
dc.collaboration | Mayo Clinic | en_US |
dc.collaboration | The University of Edinburgh | en_US |
dc.collaboration | University Medical Center Utrecht | en_US |
dc.collaboration | Institute for Clinical and Experimental Medicine | en_US |
dc.collaboration | University of Western Australia | en_US |
dc.collaboration | CHUV | en_US |
dc.collaboration | UCL Institute of Health Equity | en_US |
dc.collaboration | University of Lisbon | en_US |
dc.collaboration | Hospital de Santa Maria | en_US |
dc.collaboration | Instituto Nacional de Saude Doutor Ricardo Jorge | en_US |
dc.collaboration | Faculdade Ciencias Universidade Lisboa | en_US |
dc.collaboration | University Medical Center Groningen | en_US |
dc.collaboration | Glostrup University Hospital | en_US |
dc.collaboration | University Medical Center Utrecht | en_US |
dc.collaboration | ICIN-Netherlands Heart Institute | en_US |
dc.collaboration | Vascular Screening and Diagnostic Center | en_US |
dc.collaboration | Imperial College London | en_US |
dc.collaboration | Cyprus Cardiovascular Disease and Educational Research Trust | en_US |
dc.collaboration | Uppsala University | en_US |
dc.collaboration | National Institute of Public Health Prague | en_US |
dc.collaboration | Jagiellonian University | en_US |
dc.collaboration | Russian Academy of Medical Sciences | en_US |
dc.collaboration | Novosibirsk State Medical University | en_US |
dc.collaboration | Lithuanian University of Health Sciences | en_US |
dc.collaboration | Sir Charles Gairdner Hospital | en_US |
dc.collaboration | University of South Australia | en_US |
dc.collaboration | South Australian Health and Medical Research Institute | en_US |
dc.collaboration | Royal Perth Hospital | en_US |
dc.collaboration | Karolinska University Hospital | en_US |
dc.collaboration | Danish Cancer Society | en_US |
dc.collaboration | University of Southern Denmark | en_US |
dc.collaboration | Harvard University | en_US |
dc.collaboration | National Institute for Public Health and the Environment | en_US |
dc.collaboration | Instituto Gulbenkian Ciencia | en_US |
dc.collaboration | Biofig - Center for Biodiversity | en_US |
dc.collaboration | University of Oxford | en_US |
dc.collaboration | Boston University | en_US |
dc.collaboration | National Heart,Lung,and Blood Institute (NHLBI) | en_US |
dc.collaboration | University of Texas | en_US |
dc.collaboration | Fred Hutchinson Cancer Research Center | en_US |
dc.collaboration | McMaster University | en_US |
dc.collaboration | New York Academy of Medicine | en_US |
dc.collaboration | Kaiser Permanente Northern California | en_US |
dc.collaboration | Northwestern University | en_US |
dc.collaboration | Johns Hopkins University | en_US |
dc.collaboration | Jackson State University | en_US |
dc.collaboration | University of Minnesota | en_US |
dc.collaboration | Boston University | en_US |
dc.collaboration | Baylor College of Medicine | en_US |
dc.collaboration | Los Angeles BioMedical Research Institute | en_US |
dc.collaboration | GlaxoSmithKline | en_US |
dc.collaboration | Beth Israel Deaconess Medical Center | en_US |
dc.collaboration | University of Washington | en_US |
dc.collaboration | Group Health Cooperative | en_US |
dc.collaboration | University of Mississippi Medical Center | en_US |
dc.collaboration | University of North Carolina at Chapel Hill School of Medicine | en_US |
dc.collaboration | University of New Mexico | en_US |
dc.collaboration | Herlev Hospital | en_US |
dc.collaboration | University of Copenhagen | en_US |
dc.collaboration | Copenhagen University Hospital | en_US |
dc.collaboration | University of Warwick | en_US |
dc.subject.category | Clinical Medicine | en_US |
dc.journals | Open Access | en_US |
dc.review | Peer Reviewed | en |
dc.country | United Kingdom | en_US |
dc.country | USA | en_US |
dc.country | China | en_US |
dc.country | Netherlands | en_US |
dc.country | Germany | en_US |
dc.country | Sweden | en_US |
dc.country | Czech Republic | en_US |
dc.country | Cyprus | en_US |
dc.country | Russian Federation | en_US |
dc.country | Italy | en_US |
dc.country | Australia | en_US |
dc.country | Switzerland | en_US |
dc.country | Portugal | en_US |
dc.country | Poland | en_US |
dc.country | Lithuania | en_US |
dc.country | Canada | en_US |
dc.country | Denmark | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.identifier.doi | 10.1136/bmj.g4164 | en_US |
dc.identifier.pmid | 25011450 | - |
dc.dept.handle | 123456789/108 | en |
dc.relation.volume | 349 | en_US |
cut.common.academicyear | 2013-2014 | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 2044-6055 | - |
crisitem.journal.publisher | BMJ | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0002-6085-568X | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
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