BTEX chrono-metabolism and leukemogenic effects of night shift work in workers of gasoline stations: the EXPOSOWORK prospective panel study in Bulgaria
Journal
Journal of the National Cancer Center
Date Issued
October 2025
DOI
10.1016/j.jncc.2025.01.006
Abstract
Exposures to benzene, toluene, ethylbenzene and xylenes (BTEX) have been associated with impairment of the hematopoietic system, often leading to leukemogenesis. A prospective panel study: i) characterized the effect of night shift work (NSW) (12-hr night shift vs. 12-hr day shift) on urinary BTEX and metabolites in gasoline station workers in Plovdiv, Bulgaria, ii) evaluated the NSW effect on chrono-based BTEX genotoxic effects (as measured by 8-OHdG, a nonspecific biomarker of genotoxicity) including the influence of the downstream urinary metabolome.