Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/32829
Title: Sonothromblysis in Combination with Thrombolytic Drugs in a Rabbit Model Using MRI-Guidance
Authors: Damianou, Christakis A. 
Mylonas, Nicos 
Ioannides, Kleanthis 
Major Field of Science: Engineering and Technology
Field Category: Electrical Engineering - Electronic Engineering - Information Engineering
Keywords: Ultrasound;MRI;Stroke;Thrombolysis
Issue Date: Oct-2013
Source: Engineering, 2013, vol.5, n.10
Volume: 05
Issue: 10
Journal: Engineering 
Abstract: The potential of MRI-guided focused ultrasound (MRgFUS) combined with the thrombolytic drug recombinant tissue plasminogen activator (rt-PA), to dissolve clots in the carotid of a New Zealand rabbitin vivois evaluated. A spherically-focused transducers of 5 cmdiameter; focusing at10 cmand operating at 1 MHz was used. A pulsed ultrasound protocol was used that maintains a tissue temperature increase of less than 1℃ in the clot (called safe temperature). MRgFUS has the potentials to dissolve clots that are injected in the carotid of rabbits in vivo. It was found that the time needed for opening the carotid artery using ultrasound and rt-PA was decreased compared to just using rt-PA. The proposed protocol was monitored using Magnetic Resonance Angiography (MRA) every 1 min.
URI: https://hdl.handle.net/20.500.14279/32829
ISSN: 1947-3931
1947-394X
DOI: 10.4236/eng.2013.510B071
Type: Article
Affiliation : Cyprus University of Technology 
Frederick University of Cyprus 
Ygia Polyclinic Hospital 
Therapeutic Ultrasound 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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