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https://hdl.handle.net/20.500.14279/3172| Title: | Synthesis, solution, and structural characterization of tetrahydrofuranyl-2,2-bisphosphonic acid disodium salt | Authors: | Maltezou, Elena Stylianou, Marios Roy, Sudeshna Keramidas, Anastasios D. Drouza, Chryssoula |
Major Field of Science: | Natural Sciences | Field Category: | Biological Sciences | Keywords: | Diphosphonates;Diphosphates;Pyrophosphate synthase | Issue Date: | 2010 | Source: | Bioinorganic Chemistry and Applications, 2010, vol. 2010 | Volume: | 2010 | Journal: | Bioinorganic Chemistry and Applications | Abstract: | Bisphosphonates are biologically relevant therapeutics for bone disorders and cancer. Reaction of γ-chlorobutyric acid, phosphorus acid, and phosphorus trichloride without the use of solvent gave the tetrahydrofuranyl-2, 2-bisphosphonate sodium salt (Na2H2L). The Na 2H2L was isolated, characterized in solution by 1H, 13C, and 31P NMR spectroscopy and in solid state by single X-Ray crystallography. The crystal structure showed that the Na2H2L forms in the crystal infinite two-dimensional sheets stacked one parallel to the other. A comparison of the chelating properties of H2L2- with similar hydroxyl bisphosphonate ligands shows that the strength of the NaO(furanyl/hydroxyl) bond is directly related to the total charge of the ligand anion | URI: | https://hdl.handle.net/20.500.14279/3172 | ISSN: | 1687479X | DOI: | 10.1155/2010/563875 | Rights: | © Elena Maltezou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Type: | Article | Affiliation : | University of Cyprus Cyprus University of Technology |
| Appears in Collections: | Άρθρα/Articles |
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|---|---|---|---|---|
| 563875.pdf | 1.7 MB | Adobe PDF | View/Open |
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