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https://hdl.handle.net/20.500.14279/30899| Title: | FUS-mediated blood-brain barrier disruption for delivering anti-Aβ antibodies in 5XFAD Alzheimer's disease mice | Authors: | Antoniou, Anastasia Stavrou, Marios Evripidou, Nikolas Georgiou, Elena Kousiappa, Ioanna Koupparis, Andreas Papacostas, Savvas S. Kleopa, Kleopas A. Damianou, Christakis A. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Health Sciences | Keywords: | Alzheimer’s disease;Anti-Αβ;Antibody;BBB;Mice;Ultrasound | Issue Date: | 29-Jul-2023 | Source: | Journal of Ultrasound, 2023 | Journal: | Journal of Ultrasound | Abstract: | Amyloid-β (Aβ) peptides, the main component of amyloid plaques found in the Alzheimer's disease (AD) brain, are implicated in its pathogenesis, and are considered a key target in AD therapeutics. We herein propose a reliable strategy for non-invasively delivering a specific anti-Aβ antibody in a mouse model of AD by microbubbles-enhanced Focused Ultrasound (FUS)-mediated Blood-brain barrier disruption (BBBD), using a simple single stage MR-compatible positioning device. | URI: | https://hdl.handle.net/20.500.14279/30899 | ISSN: | 19713495 | DOI: | 10.1007/s40477-023-00805-4 | Rights: | © The Author(s) Attribution-NonCommercial-NoDerivatives 4.0 International |
Type: | Article | Affiliation : | Cyprus University of Technology Cyprus Institute of Neurology and Genetics |
| Appears in Collections: | Άρθρα/Articles |
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