Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/28012
Title: Recent Progress in Metal-Incorporated Acyclic Schiff-Base Derivatives: Biological Aspects
Authors: Nath, Bikash Dev 
Islam, Md Monarul 
Karim, Md Rezaul 
Rahman, Shofiur 
Shaikh, Md Aftab Ali 
Georghiou, Paris E. 
Menelaou, Melita 
Major Field of Science: Natural Sciences
Field Category: Chemical Sciences
Keywords: Acyclic compounds;Biological activity;Medicinal chemistry;Metal complexes;Schiff-bases
Issue Date: 12-Apr-2022
Source: ChemistrySelect, 2022, vol. 7, no. 14, articl. no. e202104290
Volume: 7
Issue: 14
Journal: ChemistrySelect 
Abstract: Schiff-base derivatives are widely used organic compounds and their metal complexes have been drawing much attention to chemists due to interesting structural features and unique properties. The presence of nitrogen containing imine groups (−C=N−) in Schiff-bases as well as in their metallic complexes and the chelating properties of these compounds are responsible for their many unique biological properties. In this review, we have summarized various acyclic Schiff-base ligands and their different metallic complexes which have been reported in the last one decade. Schiff-bases and their metal complexes have shown a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. We have reviewed and arranged the reported Schiff-base derivatives according to their diverse biological applications, especially their anti-bacterial and anti-fungal activities, anti-tumor and anti-cancer activities, anti-oxidant activities, anti-inflammatory activities and other therapeutic and medicinal properties. The other component of this work as a review of the molecular structures of various Schiff-bases since their molecular structures play a primary role in the biological properties. The presence of heteroatoms such as nitrogen, sulfur and oxygen with free electron pairs and aromatic rings in the structure of the Schiff-bases play significant roles in determining their properties.
URI: https://hdl.handle.net/20.500.14279/28012
ISSN: 23656549
DOI: 10.1002/slct.202104290
Rights: © Wiley
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation : Bangladesh Council of Scientific and Industrial Research 
Memorial University of Newfoundland 
University of Dhaka 
Cyprus University of Technology 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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