Enzymatic transformation of flavonoids and terpenoids: Structural and functional diversity of the novel derivatives
Journal
Pure and Applied Chemistry
Date Issued
January 3, 2010
DOI
10.1351/PAC-CON-09-01-19
Abstract
Flavonoids and terpenoids are promising candidates for use as functional foods and
novel therapeutics due to their prominent biological activities. However, the use of several
bioactive plant compounds is limited by low stability and solubility problems. This review
underlines the feasibility of enzymatic synthesis of novel bioactive analogs of selected
flavonoids (silybin, rutin) and terpenoids (perillyl alcohol, POH) in nonconventional reaction
systems. The effect of various parameters on the enzymatic acylation and/or glucosylation of
these phytochemicals was studied. Also, the role of the structure of the novel molecules in
relation to their biological function was investigated in various cancer cell lines.
novel therapeutics due to their prominent biological activities. However, the use of several
bioactive plant compounds is limited by low stability and solubility problems. This review
underlines the feasibility of enzymatic synthesis of novel bioactive analogs of selected
flavonoids (silybin, rutin) and terpenoids (perillyl alcohol, POH) in nonconventional reaction
systems. The effect of various parameters on the enzymatic acylation and/or glucosylation of
these phytochemicals was studied. Also, the role of the structure of the novel molecules in
relation to their biological function was investigated in various cancer cell lines.