Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/24049
Title: Barriers, facilitators, and interventions for medication adherence across chronic conditions with the highest non-adherence rates: a scoping review with recommendations for intervention development
Authors: Konstantinou, Pinelopi 
Kassianos, Angelos P. 
Georgiou, Giοrgos 
Panayides, Andreas 
Papageorgiou, Alexia 
Almas, Ioannis 
Wozniak, Greta 
Karekla, Maria 
Major Field of Science: Social Sciences
Field Category: Psychology
Keywords: Barriers;Scoping review;Medication adherence;Chronic conditions;Behavioral health interventions
Issue Date: 2021
Source: Translational behavioral medicine, 2021, vol. 10, no. 6, pp. 1390–1398
Volume: 10
Issue: 6
Start page: 1390
End page: 1398
Journal: Translational behavioral medicine 
Abstract: Medication non-adherence (MNA) constitutes a complex health problem contributing to increased economic burden and poor health outcomes. The Medication Adherence Model (MAM) supports that numerous processes are involved in medication adherence (MA). Based on the MAM and guidelines of the World Health Organization (WHO), this scoping review aimed to identify the barriers and facilitators associated with MA, and the behavioral health interventions and techniques among chronic conditions presenting with high non-adherence rates (asthma, cancer, diabetes, epilepsy, HIV/AIDS, and hypertension). PubMed, PsycINFO, and Scopus databases were screened, and 243 studies were included. A mixed methods approach was used to collate the evidence and interpret findings. The most commonly reported barriers to MA across conditions were younger age, low education, low income, high medication cost, side effects, patient beliefs/perceptions, comorbidities, and poor patient-provider communication. Additionally, digitally delivered interventions including components such as medication and condition education, motivational interviewing (MI), and reinforcement and motivational messages led to improvements in MA. This review highlights the importance of administrating multicomponent interventions digitally and personalized to the patients' individual needs and characteristics, responding to the adherence barriers faced. This is the first review examining and synthesizing evidence on barriers and facilitators to MA and behavioral health interventions used for improving MA across chronic conditions with the highest non-adherence rates and providing recommendations to researchers and clinicians. Stakeholders are called to explore methods overcoming barriers identified and developing effective multicomponent interventions that can reduce the high rates of MNA.
URI: https://hdl.handle.net/20.500.14279/24049
ISSN: 18696716
DOI: 10.1093/tbm/ibaa118
Rights: © Society of Behavioral Medicine
Type: Article
Affiliation : University of Cyprus 
University College London 
3AE Health LTD 
European University Cyprus 
University of Nicosia 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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