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https://hdl.handle.net/20.500.14279/22712
Title: | SARS-CoV-2 population-based seroprevalence studies in Europe: a scoping review | Authors: | Grant, Rebecca Dub, Timothée Andrianou, Xanthi Nohynek, Hanna Wilder-Smith, Annelies Pezzotti, Patrizio Fontanet, Arnaud |
Major Field of Science: | Medical and Health Sciences | Field Category: | Health Sciences | Keywords: | Epidemiology;Public health | Issue Date: | 1-Apr-2021 | Source: | BMJ Open, 2021, vol. 11, no. 4, articl. no. e045425 | Volume: | 11 | Issue: | 4 | Journal: | BMJ open | Abstract: | Objectives We aimed to review SARS-CoV-2 seroprevalence studies conducted in Europe to understand how they may be used to inform ongoing control strategies for COVID-19. Design Scoping review of peer-reviewed publications and manuscripts on preprint servers from January 2020 to 15 September 2020. Primary measure Seroprevalence estimate (and lower and upper CIs). For studies conducted across a country or territory, we used the seroprevalence estimate and the upper and lower CIs and compared them to the total number of reported infections to calculate the ratio of reported to expected infections. Results We identified 23 population-based seroprevalence studies conducted in Europe. Among 12 general population studies, seroprevalence ranged from 0.42% among residual clinical samples in Greece to 13.6% in an area of high transmission in Gangelt, Germany. Of the eight studies in blood donors, seroprevalence ranged from 0.91% in North-Western Germany to 23.3% in a high-transmission area in Lombardy region, Italy. In three studies which recruited individuals through employment, seroprevalence ranged from 0.5% among factory workers in Frankfurt, Germany, to 10.2% among university employees in Milan, Italy. In comparison to nationally reported cases, the extent of infection, as derived from these seroprevalence estimates, is manyfold higher and largely heterogeneous. Conclusion Exposure to the virus in Europe has not reached a level of infection that would prevent further circulation of the virus. Effective vaccine candidates are urgently required to deliver the level of immunity in the population. | URI: | https://hdl.handle.net/20.500.14279/22712 | ISSN: | 20446055 | DOI: | 10.1136/bmjopen-2020-045425 | Rights: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. Attribution-NonCommercial-NoDerivatives 4.0 International |
Type: | Article | Affiliation : | Institut Pasteur Finnish Institute for Health and Welfare Italian National Health Institute Cyprus University of Technology London School of Hygiene and Tropical Medicine University of Heidelberg Conservatoire National des Arts et Métiers |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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File | Description | Size | Format | |
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e045425.full.pdf | Fulltext | 2.32 MB | Adobe PDF | View/Open |
e045425.full.pdf | Supplementary Material | 2.36 MB | Adobe PDF | View/Open |
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