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https://hdl.handle.net/20.500.14279/1940
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Papathanassoglou, Elizabeth | - |
dc.contributor.author | Christou, Helen | - |
dc.contributor.author | Connors, Jean Marie | - |
dc.contributor.other | Παπαθανάσογλου, Ελισάβετ | - |
dc.date.accessioned | 2013-02-13T13:42:22Z | en |
dc.date.accessioned | 2013-05-16T08:36:44Z | - |
dc.date.accessioned | 2015-12-02T09:40:42Z | - |
dc.date.available | 2013-02-13T13:42:22Z | en |
dc.date.available | 2013-05-16T08:36:44Z | - |
dc.date.available | 2015-12-02T09:40:42Z | - |
dc.date.issued | 2001-02 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2001, vol. 86, no. 2, pp. 935-938 | en_US |
dc.identifier.issn | 0021972X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/1940 | - |
dc.description.abstract | The insulin-like growth factor (IGF) system is the dominant endocrine regulator of fetal growth, whereas insulin has a permissive role. Although a role for leptin in fetal growth has been suggested recently, the mechanism by which leptin may be related to fetal growth is not known; but leptin may interact with the IGF system in utero as it does in the extrauterine life. In the context of a hospital-based case control study, we collected anthropometric and demographic data and measured serum leptin, IGF-I, IGF-II, insulin, cortisol, and IGF binding protein 3 concentrations in 142 cord blood samples from full-term deliveries. Cord leptin, IGF-I, and insulin levels correlated positively with birth weight (r = 0.46, r = 0.41, and r = 0.21, respectively, P < 0.01) by univariate analysis and were significantly higher in large-for-gestational-age (LGA) infants, compared with appropriate-for-gestational-age (AGA) infants. Cord leptin concentrations correlated with insulin levels (r = 0.36, P<0.01) but not with IGF-I levels (r = 0.20). Multiple linear and logistic regression analysis demonstrated an independent positive relationship of both leptin and IGF-I with birth weight and AGA/LGA status. The positive association of leptin levels with birth weight and AGA/LGA status cannot be attributed to IGF-I. This suggests the existence of alternative mechanisms underlying leptin's associations with fetal growth that should be further explored | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Clinical Endocrinology and Metabolism | en_US |
dc.rights | © Oxford University Press | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Endocrinology | en_US |
dc.subject | Metabolism | en_US |
dc.subject | Insulin | en_US |
dc.subject | Leptin | en_US |
dc.subject | Fetus--Development | en_US |
dc.subject | Hydrocortisone | en_US |
dc.subject | Birth weight | en_US |
dc.title | Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth | en_US |
dc.type | Article | en_US |
dc.affiliation | Beth Israel Deaconess Medical Center | en |
dc.collaboration | Harvard University | en_US |
dc.subject.category | MEDICAL AND HEALTH SCIENCES | en_US |
dc.journals | Open Access | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1210/jc.86.2.935 | en_US |
dc.dept.handle | 123456789/54 | en |
dc.relation.issue | 2 | en_US |
dc.relation.volume | 86 | en_US |
cut.common.academicyear | 2000-2001 | en_US |
dc.identifier.spage | 935 | en_US |
dc.identifier.epage | 938 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 1945-7197 | - |
crisitem.journal.publisher | Oxford University Press | - |
crisitem.author.dept | Department of Nursing | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0002-7439-1492 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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