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https://hdl.handle.net/20.500.14279/1940
Τίτλος: | Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth | Συγγραφείς: | Papathanassoglou, Elizabeth Christou, Helen Connors, Jean Marie |
metadata.dc.contributor.other: | Παπαθανάσογλου, Ελισάβετ | Major Field of Science: | Medical and Health Sciences | Field Category: | MEDICAL AND HEALTH SCIENCES | Λέξεις-κλειδιά: | Endocrinology;Metabolism;Insulin;Leptin;Fetus--Development;Hydrocortisone;Birth weight | Ημερομηνία Έκδοσης: | Φεβ-2001 | Πηγή: | Journal of Clinical Endocrinology and Metabolism, 2001, vol. 86, no. 2, pp. 935-938 | Volume: | 86 | Issue: | 2 | Start page: | 935 | End page: | 938 | Περιοδικό: | Journal of Clinical Endocrinology and Metabolism | Περίληψη: | The insulin-like growth factor (IGF) system is the dominant endocrine regulator of fetal growth, whereas insulin has a permissive role. Although a role for leptin in fetal growth has been suggested recently, the mechanism by which leptin may be related to fetal growth is not known; but leptin may interact with the IGF system in utero as it does in the extrauterine life. In the context of a hospital-based case control study, we collected anthropometric and demographic data and measured serum leptin, IGF-I, IGF-II, insulin, cortisol, and IGF binding protein 3 concentrations in 142 cord blood samples from full-term deliveries. Cord leptin, IGF-I, and insulin levels correlated positively with birth weight (r = 0.46, r = 0.41, and r = 0.21, respectively, P < 0.01) by univariate analysis and were significantly higher in large-for-gestational-age (LGA) infants, compared with appropriate-for-gestational-age (AGA) infants. Cord leptin concentrations correlated with insulin levels (r = 0.36, P<0.01) but not with IGF-I levels (r = 0.20). Multiple linear and logistic regression analysis demonstrated an independent positive relationship of both leptin and IGF-I with birth weight and AGA/LGA status. The positive association of leptin levels with birth weight and AGA/LGA status cannot be attributed to IGF-I. This suggests the existence of alternative mechanisms underlying leptin's associations with fetal growth that should be further explored | URI: | https://hdl.handle.net/20.500.14279/1940 | ISSN: | 0021972X | DOI: | 10.1210/jc.86.2.935 | Rights: | © Oxford University Press | Type: | Article | Affiliation: | Beth Israel Deaconess Medical Center | Affiliation: | Harvard University | Publication Type: | Peer Reviewed |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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