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Τίτλος: Genomic variations and susceptibility to sepsis
Συγγραφείς: Papathanassoglou, Elizabeth 
Giannakopoulou, Margarita 
Bozas, Evangelos 
Major Field of Science: Medical and Health Sciences
Λέξεις-κλειδιά: Critical care nursing;Septicemia;Coagulation;Cytokines;Blood coagulation factors;Biological models
Ημερομηνία Έκδοσης: 1-Οκτ-2006
Πηγή: AACN advanced critical care, 2006, vol. 17, no. 4, pp. 394-422
Volume: 17
Issue: 4
Start page: 394
End page: 422
Περιοδικό: AACN advanced critical care 
Περίληψη: The considerable variability in septic patients' outcomes, which exceeds our understanding of the pathophysiology of sepsis and defies our current prognostic tools, has prompted investigation in the genetic variations that may predispose individuals for increased susceptibility to sepsis and adverse outcomes. This article aims to critically review current evidence from genetic association studies regarding the role of genetic polymorphisms in sepsis. Findings regarding polymorphisms in intercellular messenger mediators (cytokines), membrane-bound inflammatory receptors, intracellular signaling cascades, heat shock proteins, coagulation/fibrinolysis pathways, apoptotic mechanisms, and neuroendocrine axes are presented and discussed. Study results are often discrepant, whereas many methodological limitations, in terms of both study design and genotyping methods, may render the results difficult to generalize. Nonetheless, a role for genomic variations in sepsis outcomes has emerged. A theoretical framework for incorporation of genetic variations into individualized care planning based on complexity theory is proposed, and future prospects of microarray technology and systems modelling are discussed briefly
URI: https://hdl.handle.net/20.500.14279/1894
ISSN: 15597768
DOI: 10.4037/15597768-2006-4006
Rights: © Lippincott Williams & Wilkins
Type: Article
Affiliation: National and Kapodistrian University of Athens 
Publication Type: Peer Reviewed
Εμφανίζεται στις συλλογές:Άρθρα/Articles

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