Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/1894
DC FieldValueLanguage
dc.contributor.authorPapathanassoglou, Elizabeth-
dc.contributor.authorGiannakopoulou, Margarita-
dc.contributor.authorBozas, Evangelos-
dc.date.accessioned2013-02-13T11:06:57Zen
dc.date.accessioned2013-05-16T08:36:40Z-
dc.date.accessioned2015-12-02T09:38:42Z-
dc.date.available2013-02-13T11:06:57Zen
dc.date.available2013-05-16T08:36:40Z-
dc.date.available2015-12-02T09:38:42Z-
dc.date.issued2006-10-01-
dc.identifier.citationAACN advanced critical care, 2006, vol. 17, no. 4, pp. 394-422en_US
dc.identifier.issn15597768-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/1894-
dc.description.abstractThe considerable variability in septic patients' outcomes, which exceeds our understanding of the pathophysiology of sepsis and defies our current prognostic tools, has prompted investigation in the genetic variations that may predispose individuals for increased susceptibility to sepsis and adverse outcomes. This article aims to critically review current evidence from genetic association studies regarding the role of genetic polymorphisms in sepsis. Findings regarding polymorphisms in intercellular messenger mediators (cytokines), membrane-bound inflammatory receptors, intracellular signaling cascades, heat shock proteins, coagulation/fibrinolysis pathways, apoptotic mechanisms, and neuroendocrine axes are presented and discussed. Study results are often discrepant, whereas many methodological limitations, in terms of both study design and genotyping methods, may render the results difficult to generalize. Nonetheless, a role for genomic variations in sepsis outcomes has emerged. A theoretical framework for incorporation of genetic variations into individualized care planning based on complexity theory is proposed, and future prospects of microarray technology and systems modelling are discussed brieflyen_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofAACN advanced critical careen_US
dc.rights© Lippincott Williams & Wilkinsen_US
dc.subjectCritical care nursingen_US
dc.subjectSepticemiaen_US
dc.subjectCoagulationen_US
dc.subjectCytokinesen_US
dc.subjectBlood coagulation factorsen_US
dc.subjectBiological modelsen_US
dc.titleGenomic variations and susceptibility to sepsisen_US
dc.typeArticleen_US
dc.collaborationNational and Kapodistrian University of Athensen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.4037/15597768-2006-4006en_US
dc.dept.handle123456789/54en
dc.relation.issue4en_US
dc.relation.volume17en_US
cut.common.academicyear2006-2007en_US
dc.identifier.spage394en_US
dc.identifier.epage422en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1559-7776-
crisitem.journal.publisherAmerican Association of Critical-Care Nurses-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-7439-1492-
crisitem.author.parentorgFaculty of Health Sciences-
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