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https://hdl.handle.net/20.500.14279/18565
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Kouis, Panayiotis | - |
dc.contributor.author | Goutaki, Myrofora | - |
dc.contributor.author | Halbeisen, Florian S. | - |
dc.contributor.author | Gioti, Ifigeneia | - |
dc.contributor.author | Middleton, Nicos | - |
dc.contributor.author | Amirav, Israel | - |
dc.contributor.author | Barbato, Angelo | - |
dc.contributor.author | Behan, Laura | - |
dc.contributor.author | Boon, Mieke | - |
dc.contributor.author | Emiralioglu, Nagehan | - |
dc.contributor.author | Haarman, Eric G. | - |
dc.contributor.author | Karadag, Bulent | - |
dc.contributor.author | Koerner-Rettberg, Cordula | - |
dc.contributor.author | Lazor, Romain | - |
dc.contributor.author | Loebinger, Michael R. | - |
dc.contributor.author | Maitre, Bernard | - |
dc.contributor.author | Mazurek, Henryk | - |
dc.contributor.author | Morgan, Lucy | - |
dc.contributor.author | Nielsen, Kim Gjerum | - |
dc.contributor.author | Omran, Heymut | - |
dc.contributor.author | Özçelik, Ugur | - |
dc.contributor.author | Price, Mareike | - |
dc.contributor.author | Pogorzelski, Andrzej | - |
dc.contributor.author | Snijders, Deborah | - |
dc.contributor.author | Thouvenin, Guillaume | - |
dc.contributor.author | Werner, Claudius | - |
dc.contributor.author | Zivkovic, Zorica M. | - |
dc.contributor.author | Kuehni, Claudia E. | - |
dc.contributor.author | Yiallouros, Panayiotis K. | - |
dc.date.accessioned | 2020-07-24T05:54:37Z | - |
dc.date.available | 2020-07-24T05:54:37Z | - |
dc.date.issued | 2019-09-18 | - |
dc.identifier.citation | Respiratory Research, 2019, vol. 20, no. 1, articl. no. 212 | en_US |
dc.identifier.issn | 1465993X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/18565 | - |
dc.description.abstract | Background: Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in lobectomised and non-lobectomised patients. Methods: In the international iPCD cohort, we identified lobectomised and non-lobectomised age and sex-matched PCD patients and compared their characteristics, lung function and BMI cross-sectionally and longitudinally. Results: Among 2896 patients in the iPCD cohort, 163 from 20 centers (15 countries) underwent lung resection (5.6%). Among adult patients, prevalence of lung resection was 8.9%, demonstrating wide variation among countries. Compared to the rest of the iPCD cohort, lobectomised patients were more often females, older at diagnosis, and more often had situs solitus. In about half of the cases (45.6%) lung resection was performed before presentation to specialized PCD centers for diagnostic work-up. Compared to controls (n = 197), lobectomised patients had lower FVC z-scores (-2.41 vs-1.35, p = 0.0001) and FEV1 z-scores (-2.79 vs-1.99, p = 0.003) at their first post-lung resection assessment. After surgery, lung function continued to decline at a faster rate in lobectomised patients compared to controls (FVC z-score slope:-0.037/year Vs-0.009/year, p = 0.047 and FEV1 z-score slope:-0.052/year Vs-0.033/year, p = 0.235), although difference did not reach statistical significance for FEV1. Within cases, females and patients with multiple lobe resections had lower lung function. Conclusions: Prevalence of lung resection in PCD varies widely between countries, is often performed before PCD diagnosis and overall is more frequent in patients with delayed diagnosis. After lung resection, compared to controls most lobectomised patients have poorer and continuing decline of lung function despite lung resection. Further studies benefiting from prospective data collection are needed to confirm these findings. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Respiratory Research | en_US |
dc.rights | © The Author(s) | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Ciliary motility disorders (MeSH) | en_US |
dc.subject | Kartagener syndrome (MeSH) | en_US |
dc.subject | Lobectomy | en_US |
dc.title | Prevalence and course of disease after lung resection in primary ciliary dyskinesia: A cohort & nested case-control study | en_US |
dc.type | Article | en_US |
dc.collaboration | University of Cyprus | en_US |
dc.collaboration | University of Bern | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.collaboration | University of Alberta | en_US |
dc.collaboration | University of Padova | en_US |
dc.collaboration | University Hospital Southampton NHS Foundation Trust | en_US |
dc.collaboration | University of Southampton | en_US |
dc.collaboration | University Hospital Gasthuisberg Leuven | en_US |
dc.collaboration | Hacettepe University | en_US |
dc.collaboration | Vrije Universiteit Brussel | en_US |
dc.collaboration | Marmara University | en_US |
dc.collaboration | University Children's Hospital of Ruhr | en_US |
dc.collaboration | University Bochum | en_US |
dc.collaboration | Lausanne University Hospital | en_US |
dc.collaboration | National Reference Centre for Rare Pulmonary Diseases | en_US |
dc.collaboration | Royal Brompton and Harefield NHS Foundation Trust | en_US |
dc.collaboration | Université Paris Est Créteil | en_US |
dc.collaboration | Instytut Gruźlicy i ChoróbPłuc | en_US |
dc.collaboration | University of Sydney | en_US |
dc.collaboration | Copenhagen University Hospital | en_US |
dc.collaboration | University Hospital Muenster | en_US |
dc.collaboration | Hannover Medical School | en_US |
dc.collaboration | Sorbonne Universités | en_US |
dc.collaboration | Medical Centre dr Dragisa Misovic | en_US |
dc.collaboration | Business Academy in Novi Sad | en_US |
dc.collaboration | Shakolas Educational Center of Clinical Medicine | en_US |
dc.collaboration | Tel Aviv Medical Center | en_US |
dc.collaboration | Helios Hospital Schwerin | en_US |
dc.subject.category | Clinical Medicine | en_US |
dc.journals | Open Access | en_US |
dc.country | Cyprus | en_US |
dc.country | Switzerland | en_US |
dc.country | Canada | en_US |
dc.country | Italy | en_US |
dc.country | United Kingdom | en_US |
dc.country | Belgium | en_US |
dc.country | Turkey | en_US |
dc.country | Netherlands | en_US |
dc.country | Germany | en_US |
dc.country | France | en_US |
dc.country | Poland | en_US |
dc.country | Australia | en_US |
dc.country | Denmark | en_US |
dc.country | Serbia | en_US |
dc.country | Israel | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1186/s12931-019-1183-y | en_US |
dc.identifier.pmid | 31533829 | - |
dc.identifier.scopus | 2-s2.0-85072516815 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85072516815 | - |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 20 | en_US |
cut.common.academicyear | 2019-2020 | en_US |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 1465-993X | - |
crisitem.journal.publisher | Springer Nature | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.dept | Department of Nursing | - |
crisitem.author.dept | Cyprus International Institute for Environmental and Public Health | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0003-0511-5352 | - |
crisitem.author.orcid | 0000-0001-6358-8591 | - |
crisitem.author.orcid | 0000-0002-8339-9285 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
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