Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/18524
Title: A Scoping Review on the Characteristics of Human Exposome Studies
Authors: Haddad, Nadine 
Andrianou, Xanthi 
Makris, Konstantinos C. 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Keywords: Cohorts;Exposome;Domains;EWAS;Omics;Environmental health;Personalized medicine;Trials
Issue Date: Dec-2019
Source: Current Pollution Reports, vol. 5, no. 4, pp. 378–393
Volume: 5
Issue: 4
Start page: 378
End page: 393
Journal: Current Pollution Reports 
Abstract: Embraced as a breaking through methodological framework, the exposome is accompanied by novel exposure assessment methods and data processing tools or models. However, systematic mapping of the landscape of exposome studies, including their characteristics, components, tools and language has not been done so far. We conducted a scoping review to answer the question: “Which main domains of the human exposome have been included in the literature and which metrics of exposure(s)/outcome(s) have been used?” We performed a comprehensive search of human studies containing the word “exposom*” and published up to March 8, 2019. We screened 1133 records and 82 studies were included in the analysis. Most studies took place in Europe. Data analysis showed the non-systematic use of the exposome term. Most studies had a longitudinal design (n = 30, 37%), were conducted on adults (n = 40, 51%), and had a clearly defined health outcome in methodology (n = 48, 61%). Omics tools, such as metabolomics were used in 38 studies (49%), while environment-wide association analysis was used in 9 studies (11%). Thirty-seven (48%) studies included all three exposome domains (general external, specific external and internal) while 33 (42%) studies included two. Despite the large number of environmental components that comprise each of the exposome domains, only a subset has been currently studied. An optimized consideration of the components from all exposome domains, as well as the standardization of the exposure and outcome assessment methods is warranted to advance the utility of the human exposome concept.
URI: https://hdl.handle.net/20.500.14279/18524
ISSN: 21986592
DOI: 10.1007/s40726-019-00130-7
Rights: © 2019, The Author(s).
Type: Article
Affiliation : Cyprus University of Technology 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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