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https://hdl.handle.net/20.500.14279/14877
Τίτλος: | 'Closing the loop' in biological systems modeling-from the in silico to the in vitro | Συγγραφείς: | Kiparissides, Alexandros Koutinas, Michalis Kontoravdi, Cleo Mantalaris, Athanasios A. Pistikopoulos, Efstratios N. |
Major Field of Science: | Natural Sciences | Field Category: | Biological Sciences | Λέξεις-κλειδιά: | Model analysis;Biological systems model development;Sensitivity analysis;Design of experiments | Ημερομηνία Έκδοσης: | Ιου-2011 | Πηγή: | Automatica, 2011, vol. 47, no. 6, pp. 1147-1155 | Volume: | 47 | Issue: | 6 | Start page: | 1147 | End page: | 1155 | Περιοδικό: | Automatica | Περίληψη: | This work presents a holistic 'closed loop' approach for the development of models of biological systems. The ever-increasing availability of experimental information necessitates the advancement of a systematic methodology to organise and utilise these data. Herein, we present a biological model building framework that maps the treatment of the information from the initial conception of the model, through its experimental validation and finally to its application in model-based optimisation studies. We highlight and discuss current issues associated with the development of mathematical models of biological systems and share our perspective towards a holistic 'closed loop' approach that will facilitate the control of the in vitro through the in silico. | URI: | https://hdl.handle.net/20.500.14279/14877 | ISSN: | 00051098 | DOI: | 10.1016/j.automatica.2011.01.013 | Rights: | © Elsevier | Type: | Article | Affiliation: | Imperial College London Cyprus University of Technology |
Publication Type: | Peer Reviewed |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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