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https://hdl.handle.net/20.500.14279/1455
Πεδίο DC | Τιμή | Γλώσσα |
---|---|---|
dc.contributor.author | Fan, Zhigang | - |
dc.contributor.author | Spencer, Joel A. | - |
dc.contributor.author | Pitsillides, Costas | - |
dc.contributor.author | Lü, Yan | - |
dc.contributor.author | Singh, Gurbakhshish | - |
dc.contributor.author | Kim, Pilhan | - |
dc.contributor.author | Yun, Seok Hyun Andy | - |
dc.contributor.author | Toxavidis, Vasilis | - |
dc.contributor.author | Strom, Terry | - |
dc.contributor.author | Lin, Charles P. | - |
dc.contributor.author | Koulmanda, Maria | - |
dc.date.accessioned | 2013-02-22T13:34:12Z | en |
dc.date.accessioned | 2013-05-17T05:22:28Z | - |
dc.date.accessioned | 2015-12-02T10:05:27Z | - |
dc.date.available | 2013-02-22T13:34:12Z | en |
dc.date.available | 2013-05-17T05:22:28Z | - |
dc.date.available | 2015-12-02T10:05:27Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | Nature medicine, 2010, vol. 16, no. 6, pp. 718-722 | en_US |
dc.identifier.issn | 1546170X | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/1455 | - |
dc.description.abstract | Here we present methods to longitudinally track islet allograft–infiltrating T cells in live mice by endoscopic confocal microscopy and to analyze circulating T cells by in vivo flow cytometry. We developed a new reporter mouse whose T cell subsets express distinct, 'color-coded' proteins enabling in vivo detection and identification of effector T cells (Teff cells) and discrimination between natural and induced regulatory T cells (nTreg and iTreg cells). Using these tools, we observed marked differences in the T cell response in recipients receiving tolerance-inducing therapy (CD154-specific monoclonal antibody plus rapamycin) compared to untreated controls. These results establish real-time cell tracking as a powerful means to probe the dynamic cellular interplay mediating immunologic rejection or transplant tolerance | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Nature medicine | en_US |
dc.rights | © Nature America | en_US |
dc.subject | Flow cytometry | en_US |
dc.subject | Photoacoustic effect | en_US |
dc.subject | Vivo flow | en_US |
dc.title | In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response | en_US |
dc.type | Article | en_US |
dc.affiliation | Boston University | en |
dc.collaboration | Harvard University | en_US |
dc.collaboration | Tufts University | en_US |
dc.collaboration | Boston University | en_US |
dc.subject.category | Electrical Engineering - Electronic Engineering - Information Engineering | en_US |
dc.journals | Subscription | en_US |
dc.country | United States | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Natural Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.1038/nm.2155 | en_US |
dc.identifier.pmid | 20495571 | - |
dc.dept.handle | 123456789/54 | en |
dc.relation.issue | 6 | en_US |
dc.relation.volume | 16 | en_US |
cut.common.academicyear | 2009-2010 | en_US |
dc.identifier.spage | 718 | en_US |
dc.identifier.epage | 722 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.journal.journalissn | 1546-170X | - |
crisitem.journal.publisher | Springer Nature | - |
crisitem.author.dept | Department of Mechanical Engineering and Materials Science and Engineering | - |
crisitem.author.faculty | Faculty of Engineering and Technology | - |
crisitem.author.parentorg | Faculty of Engineering and Technology | - |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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