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Title: Valuation of the in vivo contrast using fast spin echo MRI sequences between tissues and thermal lesions in rabbit produced by high intensity focused ultrasound
Authors: Damianou, Christakis A. 
Milonas, Nikos 
Ioannides, Kleanthis
Couppis, Andreas
Iosif, Demitris 
Hadjisavas, Venediktos 
Major Field of Science: Engineering and Technology
Field Category: Electrical Engineering - Electronic Engineering - Information Engineering
Keywords: Brain;Heart;HIFU;Kidney;Liver;MRI;Pancreas
Issue Date: 30-Mar-2010
Source: 9th International Symposium on Therapeutic Ultrasound, ISTU 2009; Aix-en-Provence; France; 24 September 2009 through 26 September 2009
Volume: 1215
Conference: International Symposium on Therapeutic Ultrasound 
Abstract: In this paper the goal was to measure the contrast to noise ratio (CNR) of fast spin echo (FSE) magnetic resonance imaging (MRI) sequences in detecting thermal lesions created by high intensity focused ultrasound (HIFU) in rabbit kidney, liver, heart, and brain and lamb pancreas. A spherically focused transducer was used which is navigated inside MRI by a custom made positioning device. A simple simulation model was developed which predicts the CNR for the two FSE MRI sequences. The maximum contrast measured with T1-W FSE ranges from 10 to 25. For all 5 tissues of interest if one uses TR between 400 and 500 ms the contrast is maximized. The T1, and T2 value of lesion depends strongly on the host tissue and is always lower than the host tissue. The greater the difference in T1 value, the greater the CNR. The simulated model for predicting the CNR was proven successful. The CNR measured with T2-W FSE varies between 12 and 15 for all 5 tissues. With T2-W FSE if one uses TE between 40 and 50 ms, the contrast is maximized. © 2010 American Institute of Physics.
Description: Part of AIP Conference Proceedings, Volume 1215
ISBN: 9780735407589
DOI: 10.1063/1.3367194
Rights: © AIP Publishing LLC
Type: Conference Papers
Affiliation : Frederick University 
Medsonic Ltd 
Ygia Polyclinic Hospital 
Appears in Collections:Δημοσιεύσεις σε συνέδρια /Conference papers or poster or presentation

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