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Τίτλος: First-trimester ductus venosus screening for cardiac defects: a meta-analysis
Συγγραφείς: Papatheodorou, Stefania 
Makrydimas, George V. 
Ioannidis, John P. A. 
Evangelou, Evangelos 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Λέξεις-κλειδιά: Chromosomal abnormalities;Congenital heart disease;Ductus venosus;Nuchal translucency
Ημερομηνία Έκδοσης: Νοε-2011
Πηγή: BJOG: An International Journal of Obstetrics and Gynaecology, 2011, vol. 118, no. 12, pp. 1438-1445
Volume: 118
Issue: 12
Start page: 1438
End page: 1445
Περιοδικό: BJOG: An International Journal of Obstetrics and Gynaecology 
Περίληψη: Background Heart defects are the most common congenital abnormalities. Objective We aimed to evaluate in a meta-analysis the screening performance of abnormal ductus venosus (DV) Doppler waveform for detection of congenital heart disease (CHD) in chromosomally normal fetuses. Search strategy Studies were retrieved from a search of MEDLINE, ISI, SCOPUS and EMBASE (from 1999 to March 2011) using the keywords 'ductus venosus', 'DV', 'chromosomal abnormalities', 'congenital heart disease' and 'nuchal translucency'. Selection criteria We considered all studies that examined the diagnostic performance of DV in the first trimester for CHD in chromosomally normal fetuses. We included studies that were limited to fetuses with increased nuchal translucency (NT), normal NT, and studies that examined fetuses regardless of NT status. Data collection and analysis Seven studies (n = 50 354) regardless of the NT status, nine studies (n = 2908) with increased NT and seven studies (n = 47 610) with normal NT were included in the meta-analysis. We drew hierarchical summary receiver operating characteristic (HSROC) curves using the parameters of the fitted models. Main results In populations including participants regardless of NT status, the summary sensitivity and specificity of DV for detecting CHD were 50 and 93%, respectively. In participants with increased NT, the summary sensitivity and specificity were 83 and 80%, and in those with normal NT, they were 19 and 96%, respectively. Authors' conclusions The estimated performance of DV assessment for detection of CHD in chromosomally normal fetuses can be considered in evaluating the potential use and limitations of this screening test.
URI: https://hdl.handle.net/20.500.14279/1254
ISSN: 14710528
DOI: 10.1111/j.1471-0528.2011.03029.x
Rights: © Mitha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Type: Article
Affiliation: University of Ioannina 
Stanford University 
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