Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/1221
Title: ApoB/ApoA1 ratio and subclinical atherosclerosis
Authors: Panayiotou, Andrie G. 
Griffin, Maura 
Georgiou, Niki 
Bond, Dawn 
Tyllis, Theodosis 
Tziakouri-Shiakalli, Chrysa 
Nicolaides, Andrew 
Fessas, Charis 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: Apolipoprotein B (ApoB);Apolipoprotein A-I (ApoA1);Low density lipoprotein (LDL);ApoB/ApoA1 ratio;Atherosclerosis
Issue Date: Feb-2008
Source: International angiology: a journal of the International Union of Angiology, 2008, vol. 27, iss. 1, pp. 74-80
Volume: 27
Issue: 1
Start page: 74
End page: 80
Link: http://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2008N01A0074
Journal: International angiology 
Abstract: Aim. It has been demonstrated that an increased apolipoprotein B (ApoB)/apolipoprotein A-I (ApoA1) ratio is associated with atherogenic low density lipoprotein (LDL) particles and the development of clinical cardiovascular disease. The aim of this study was to test the hypothesis that ApoB/ApoA1 ratio is associated with early subclinical atherosclerosis as demonstrated by ultrasonic measurements. Methods. Both common carotid and common femoral bifurcations have been scanned with high-resolution ultrasound in 767 volunteers over the age of 40. The latter consisted of 95% of the population of two randomly selected areas. IMTcc, IMTmax (including plaques), total plaque thickness (TPT) (the sum of the thickest plaques present at each bifurcation in cm) and black plaque burden (BPB) (TPT means plaque type) using the Widder classification with type 1 being the most hyperechoic and calcified and type 5 the most hypoechoic plaque were recorded. A medical history was taken with emphasis on risk factors present and a fasting lipid profile including ApoB and ApoA1 was determined. Results. In the total population (N.=767) the mean (±SD) ApoB/ApoA1 ratio was 0.85 (±0.22). In linear regression analysis, the Apob/ApoA1 ratio was significantly associated with all the ultrasonic measurements of early atherosclerosis (intima media thickness, IMTcc, IMTmax, TPT and BPB). These findings remained significant after correcting for age, gender, smoking, hypertension and diabetes (P<0.001 for all). Conclusion. The results indicate that a high ApoB/ApoA1 ratio is associated not only with early atherosclerosis but also with hypoechoic (BPB) and by inference unstable plaques.
URI: https://hdl.handle.net/20.500.14279/1221
ISSN: 18271839
Rights: © Edizioni Minerva Medica
Type: Article
Affiliation : University of Cyprus 
Vascular Screening and Diagnostic Center 
Nicosia General Hospital 
Cyprus Heart Foundation 
Imperial College London 
Cyprus Institute of Neurology and Genetics 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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