Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/11704
Title: | Possible obesogenic effects of bisphenols accumulation in the human brain | Authors: | Charisiadis, Pantelis Andrianou, Xanthi Van Der Meer, Thomas P. Den Dunnen, Wilfred F. A. Swaab, Dick F. Wolffenbuttel, Bruce H. R. Makris, Konstantinos C. Van Vliet-Ostaptchouk, Jana V. |
Major Field of Science: | Medical and Health Sciences | Field Category: | Basic Medicine | Keywords: | Bisphenol A;Bisphenol F;Chlorinated BPA;Bisphenols | Issue Date: | 1-Dec-2018 | Source: | Scientific Reports, 2018, vol. 8, no. 1 | Volume: | 8 | Issue: | 1 | Journal: | Scientific Reports | Abstract: | Evidence of bisphenols’ obesogenic efects on humans is mixed and inconsistent. We aimed to explore the presence of bisphenol A (BPA), bisphenol F (BPF) and chlorinated BPA (ClBPA), collectively called the bisphenols, in diferent brain regions and their association with obesity using post-mortem hypothalamic and white matter brain material from twelve pairs of obese (body mass index (BMI) >30kg/m2) and normal-weight individuals (BMI <25kg/m2). Mean ratios of hypothalamus:white matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95, respectively, suggesting no preferential accumulation of the bisphenols in the grey matter (hypothalamic) or white matter-enriched brain areas. We observed diferences in hypothalamic concentrations among the bisphenols, with highest median level detected for ClBPA (median: 2.4ng/g), followed by BPF (2.2ng/g) and BPA (1.2ng/g); similar ranking was observed for the white matter samples (median for: ClBPA-2.5ng/g, BPF-2.3ng/g, and BPA1.0ng/g). Furthermore, all bisphenol concentrations, except for white-matter BPF were associated with obesity (p<0.05). This is the frst study reporting the presence of bisphenols in two distinct regions of the human brain. Bisphenols accumulation in the white matter-enriched brain tissue could signify that they are able to cross the blood-brain barrier. | ISSN: | 29844501 | DOI: | 10.1038/s41598-018-26498-y | Rights: | © The Author(s) | Type: | Article | Affiliation : | Cyprus University of Technology University of Groningen Royal Netherlands Academy of Arts and Sciences |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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File | Description | Size | Format | |
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s41598-018-26498-y.pdf | Fulltext | 1.17 MB | Adobe PDF | View/Open |
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