Possible obesogenic effects of bisphenols accumulation in the human brain
Journal
Scientific Reports
Date Issued
December 1, 2018
DOI
10.1038/s41598-018-26498-y
Abstract
Evidence of bisphenols’ obesogenic efects on humans is mixed and inconsistent. We aimed to explore
the presence of bisphenol A (BPA), bisphenol F (BPF) and chlorinated BPA (ClBPA), collectively called
the bisphenols, in diferent brain regions and their association with obesity using post-mortem
hypothalamic and white matter brain material from twelve pairs of obese (body mass index (BMI)
>30kg/m2) and normal-weight individuals (BMI <25kg/m2). Mean ratios of hypothalamus:white
matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95, respectively, suggesting no preferential
accumulation of the bisphenols in the grey matter (hypothalamic) or white matter-enriched brain areas.
We observed diferences in hypothalamic concentrations among the bisphenols, with highest median
level detected for ClBPA (median: 2.4ng/g), followed by BPF (2.2ng/g) and BPA (1.2ng/g); similar
ranking was observed for the white matter samples (median for: ClBPA-2.5ng/g, BPF-2.3ng/g, and BPA1.0ng/g).
Furthermore, all bisphenol concentrations, except for white-matter BPF were associated with
obesity (p<0.05). This is the frst study reporting the presence of bisphenols in two distinct regions of
the human brain. Bisphenols accumulation in the white matter-enriched brain tissue could signify that
they are able to cross the blood-brain barrier.
the presence of bisphenol A (BPA), bisphenol F (BPF) and chlorinated BPA (ClBPA), collectively called
the bisphenols, in diferent brain regions and their association with obesity using post-mortem
hypothalamic and white matter brain material from twelve pairs of obese (body mass index (BMI)
>30kg/m2) and normal-weight individuals (BMI <25kg/m2). Mean ratios of hypothalamus:white
matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95, respectively, suggesting no preferential
accumulation of the bisphenols in the grey matter (hypothalamic) or white matter-enriched brain areas.
We observed diferences in hypothalamic concentrations among the bisphenols, with highest median
level detected for ClBPA (median: 2.4ng/g), followed by BPF (2.2ng/g) and BPA (1.2ng/g); similar
ranking was observed for the white matter samples (median for: ClBPA-2.5ng/g, BPF-2.3ng/g, and BPA1.0ng/g).
Furthermore, all bisphenol concentrations, except for white-matter BPF were associated with
obesity (p<0.05). This is the frst study reporting the presence of bisphenols in two distinct regions of
the human brain. Bisphenols accumulation in the white matter-enriched brain tissue could signify that
they are able to cross the blood-brain barrier.
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