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Τίτλος: In vitro model improves the prediction of soil arsenic bioavailability: worst-case scenario
Συγγραφείς: Quazi, Shahida 
Nagar, Rachana 
Sarkar, Dibyendu 
Datta, Rupali K. 
Sylvia, Victor L. 
Makris, Konstantinos C. 
Major Field of Science: Natural Sciences
Field Category: Earth and Related Environmental Sciences
Λέξεις-κλειδιά: Arsenic bioavailability;BALB/c mice;Bioaccessibility;Bioaccessible;Contaminated soils;Crystalline solids;In vitro modeling;In vitro testing;In-vitro;In-vivo;Oral bioavailability;Oxidation states;Residence time;Solution chemistry;Solution ratio;Worst-case scenario
Ημερομηνία Έκδοσης: 15-Αυγ-2008
Πηγή: Environmental Science and Technology, 2008, vol. 42, iss. 16, pp. 6278-6284
Volume: 42
Issue: 16
Start page: 6278
End page: 6284
Περιοδικό: Environmental Science & Technology 
Περίληψη: There is a strong interest in developing an in vitro arsenic (As) model that satisfactorily estimates the variability in in vivo relative oral bioavailability (RBA) measurements. Several in vitro tests have been developed, but none is universally accepted due to their limited success in predicting soil As RBA. A suite of amorphous and crystalline solid As phases were chosen, utilizing a worst-case scenario (VVCS) that simulated fasting children's gastric solution chemistry. The objectives of this study were to (i) determine the effects of residence time, pH, and solid-to-solution ratio on As bioaccessibility and speciation in the in vitro gastric test; (ii) provide the fundamental basis for an optimized in vitro model constrained by the WCS; and (iii) validate the optimized in vitro test with the in vivo RBA obtained with BALB/c mice. The gastric pH was the only significant (p < 0.05) factor influencing solid As bioaccessibility. Bioaccessible As retained the oxidation state after its release from the solid into the gastric solution. The optimized in vitro model adequately predicted RBA values for a suite of solid As phases typically encountered in soils, with the exception of aluminum-based solids. This study is an excellent starting point for developing an in vitro test applicable to different As-contaminated soils.
URI: https://hdl.handle.net/20.500.14279/1076
ISSN: 15205851
DOI: 10.1021/es800476p
Rights: © American Chemical Society
Type: Article
Affiliation: University of Texas 
Harvard University 
University of Texas Health Science Center 
Publication Type: Peer Reviewed
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