Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/1076
DC FieldValueLanguage
dc.contributor.authorQuazi, Shahida-
dc.contributor.authorNagar, Rachana-
dc.contributor.authorSarkar, Dibyendu-
dc.contributor.authorDatta, Rupali K.-
dc.contributor.authorSylvia, Victor L.-
dc.contributor.authorMakris, Konstantinos C.-
dc.date.accessioned2015-03-23T08:08:21Z-
dc.date.accessioned2015-12-02T08:48:02Z-
dc.date.available2015-03-23T08:08:21Z-
dc.date.available2015-12-02T08:48:02Z-
dc.date.issued2008-08-15-
dc.identifier.citationEnvironmental Science and Technology, 2008, vol. 42, iss. 16, pp. 6278-6284en_US
dc.identifier.issn15205851-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/1076-
dc.description.abstractThere is a strong interest in developing an in vitro arsenic (As) model that satisfactorily estimates the variability in in vivo relative oral bioavailability (RBA) measurements. Several in vitro tests have been developed, but none is universally accepted due to their limited success in predicting soil As RBA. A suite of amorphous and crystalline solid As phases were chosen, utilizing a worst-case scenario (VVCS) that simulated fasting children's gastric solution chemistry. The objectives of this study were to (i) determine the effects of residence time, pH, and solid-to-solution ratio on As bioaccessibility and speciation in the in vitro gastric test; (ii) provide the fundamental basis for an optimized in vitro model constrained by the WCS; and (iii) validate the optimized in vitro test with the in vivo RBA obtained with BALB/c mice. The gastric pH was the only significant (p < 0.05) factor influencing solid As bioaccessibility. Bioaccessible As retained the oxidation state after its release from the solid into the gastric solution. The optimized in vitro model adequately predicted RBA values for a suite of solid As phases typically encountered in soils, with the exception of aluminum-based solids. This study is an excellent starting point for developing an in vitro test applicable to different As-contaminated soils.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofEnvironmental Science & Technologyen_US
dc.rights© American Chemical Societyen_US
dc.subjectArsenic bioavailabilityen_US
dc.subjectBALB/c miceen_US
dc.subjectBioaccessibilityen_US
dc.subjectBioaccessibleen_US
dc.subjectContaminated soilsen_US
dc.subjectCrystalline solidsen_US
dc.subjectIn vitro modelingen_US
dc.subjectIn vitro testingen_US
dc.subjectIn-vitroen_US
dc.subjectIn-vivoen_US
dc.subjectOral bioavailabilityen_US
dc.subjectOxidation statesen_US
dc.subjectResidence timeen_US
dc.subjectSolution chemistryen_US
dc.subjectSolution ratioen_US
dc.subjectWorst-case scenarioen_US
dc.titleIn vitro model improves the prediction of soil arsenic bioavailability: worst-case scenarioen_US
dc.typeArticleen_US
dc.collaborationUniversity of Texasen_US
dc.collaborationHarvard Universityen_US
dc.collaborationUniversity of Texas Health Science Centeren_US
dc.subject.categoryEarth and Related Environmental Sciencesen_US
dc.journalsSubscriptionen_US
dc.reviewPeer Revieweden
dc.countryUnited Statesen_US
dc.subject.fieldNatural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1021/es800476pen_US
dc.dept.handle123456789/54en
dc.relation.issue16en_US
dc.relation.volume42en_US
cut.common.academicyear2008-2009en_US
dc.identifier.spage6278en_US
dc.identifier.epage6284en_US
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn1520-5851-
crisitem.journal.publisherAmerican Chemical Society-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.parentorgFaculty of Health Sciences-
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