Organic vanadium compounds - Transition state analogy with organic phosphorus compounds
Journal
Phosphorus, Sulfur and Silicon and Related Elements
Date Issued
January 1, 1996
Abstract
Vanadium compounds, particularly in oxidation state V, are potent inhibitors of phosphoryl group transfer enzymes. In this paper the existance of a correlation between the coordination geometry of a series of vanadium dipicolinate complexes and their potency as inhibitors for chicken intestinal alkaline phosphatase is examined. We find that within a limited series of vanadium compounds the five-coordinate derivatives are the most potent inhibitors.
Subjects