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Title: Investigation of thyroid nodules in the female population in Cyprus and in Romania
Authors: Piciu, Andra 
Andrianou, Xanthi 
Irimie, Alexandru 
Bălăcescu, Ovidiu 
Zira, Christina 
Bărbuş, Elena 
Peştean, Claudiu 
Aristeidou, Kyriakos 
Theofanous, Thalia 
Agathokleous, Margerita 
Piciu, Doina 
Makris, Konstantinos C. 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: Bisphenol A;Environmental exposure;Thyroid cancer;Thyroid nodules;Thyroiditis
Issue Date: 14-Aug-2015
Source: Clujul Medical, 2015, vol. 88, no. 4, pp. 494-499.
Volume: 88
Issue: 4
Start page: 494
End page: 499
DOI: 10.15386/cjmed-518
Journal: Clujul Medical 
Abstract: Background and aims. The most common thyroid disorders, with an increasing detection worldwide, are the thyroid nodules and thyroiditis, which leads to an increase of thyroid cancer incidence . In two different countries with a different exposure to risk factors for thyroid cancer, such as Cyprus and Romania, the rank of thyroid cancer among other neoplasms is very different: the 3rd most prevalent cancer among females in Cyprus and the 12th in Romania, respectively. Environmental chemicals, such as bisphenol A have a proven effect on the thyroid function. However, the relation between the exposure to the endocrine disruptor and the development of thyroid nodules, with a potential of malignant transformation has not been previously studied. The aim of the study was to investigate the potential factors that lead to the difference of thyroid nodules incidence in the mentioned countries. Methods. A pilot case-control study has been conducted in 2014-2015 in the "Prof. Dr. Ion Chiricuţă" Institute of Oncology, Cluj-Napoca, Romania and the Endocrinology Department of Archbishop Makarios III Hospital, Nicosia, Cyprus. Females older than 20 years with no medical history were recruited. Cases were women with ultrasound-confirmed thyroid nodules of size >3mm. Controls were women without thyroid nodules after ultrasound confirmation. All participants provided blood samples for measurements of the thyroid stimulating hormone (TSH), free thyroxin (FT4), anti- thyroglobulin (ATg) and anti-thyroid peroxidase (ATPO); urine samples. Demographics, anthropometrics and other relevant information were provided through the administration of a questionnaire. Results. In Romania we selected 51 patients with thyroid nodules (case group) and 41 without thyroid nodules (control group) and in Cyprus 57 cases, respectively 65 controls. After the statistical analysis of the data collected we observed statistically significant differences between the populations of the two countries regarding BMI and the value of the thyroid hormones and antibodies. Conclusions. Using the data observed in this study, differences were found between Cyprus and Romania among females with thyroid nodules the BMI, and the level of thyroid hormones had statistically significant differences. This study reports preliminary data, further analysis of environmental exposures to chemical factors that might have a certain influence over the thyroid in the two countries will follow.
ISSN: 12222119
DOI: 10.15386/cjmed-518
Rights: © Iuliu Hatieganu Medical University Press
Type: Article
Affiliation : Prof. Dr. Ion Chiricuta Institute of Oncology 
Iuliu Hatieganu University of Medicine and Pharmacy 
Cyprus University of Technology 
Hospital Archbishop Makarios III 
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