Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/9543
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dc.contributor.authorPiciu, Andra-
dc.contributor.authorAndrianou, Xanthi-
dc.contributor.authorIrimie, Alexandru-
dc.contributor.authorBălăcescu, Ovidiu-
dc.contributor.authorZira, Christina-
dc.contributor.authorBărbuş, Elena-
dc.contributor.authorPeştean, Claudiu-
dc.contributor.authorAristeidou, Kyriakos-
dc.contributor.authorTheofanous, Thalia-
dc.contributor.authorAgathokleous, Margerita-
dc.contributor.authorPiciu, Doina-
dc.contributor.authorMakris, Konstantinos C.-
dc.date.accessioned2017-02-08T15:48:26Z-
dc.date.available2017-02-08T15:48:26Z-
dc.date.issued2015-08-14-
dc.identifier.citationClujul Medical, 2015, vol. 88, no. 4, pp. 494-499.en_US
dc.identifier.issn12222119-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/9543-
dc.description.abstractBackground and aims. The most common thyroid disorders, with an increasing detection worldwide, are the thyroid nodules and thyroiditis, which leads to an increase of thyroid cancer incidence . In two different countries with a different exposure to risk factors for thyroid cancer, such as Cyprus and Romania, the rank of thyroid cancer among other neoplasms is very different: the 3rd most prevalent cancer among females in Cyprus and the 12th in Romania, respectively. Environmental chemicals, such as bisphenol A have a proven effect on the thyroid function. However, the relation between the exposure to the endocrine disruptor and the development of thyroid nodules, with a potential of malignant transformation has not been previously studied. The aim of the study was to investigate the potential factors that lead to the difference of thyroid nodules incidence in the mentioned countries. Methods. A pilot case-control study has been conducted in 2014-2015 in the "Prof. Dr. Ion Chiricuţă" Institute of Oncology, Cluj-Napoca, Romania and the Endocrinology Department of Archbishop Makarios III Hospital, Nicosia, Cyprus. Females older than 20 years with no medical history were recruited. Cases were women with ultrasound-confirmed thyroid nodules of size >3mm. Controls were women without thyroid nodules after ultrasound confirmation. All participants provided blood samples for measurements of the thyroid stimulating hormone (TSH), free thyroxin (FT4), anti- thyroglobulin (ATg) and anti-thyroid peroxidase (ATPO); urine samples. Demographics, anthropometrics and other relevant information were provided through the administration of a questionnaire. Results. In Romania we selected 51 patients with thyroid nodules (case group) and 41 without thyroid nodules (control group) and in Cyprus 57 cases, respectively 65 controls. After the statistical analysis of the data collected we observed statistically significant differences between the populations of the two countries regarding BMI and the value of the thyroid hormones and antibodies. Conclusions. Using the data observed in this study, differences were found between Cyprus and Romania among females with thyroid nodules the BMI, and the level of thyroid hormones had statistically significant differences. This study reports preliminary data, further analysis of environmental exposures to chemical factors that might have a certain influence over the thyroid in the two countries will follow.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofClujul Medicalen_US
dc.rights© Iuliu Hatieganu Medical University Pressen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectBisphenol Aen_US
dc.subjectEnvironmental exposureen_US
dc.subjectThyroid canceren_US
dc.subjectThyroid nodulesen_US
dc.subjectThyroiditisen_US
dc.titleInvestigation of thyroid nodules in the female population in Cyprus and in Romaniaen_US
dc.typeArticleen_US
dc.doi10.15386/cjmed-518en_US
dc.collaborationProf. Dr. Ion Chiricuta Institute of Oncologyen_US
dc.collaborationIuliu Hatieganu University of Medicine and Pharmacyen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationHospital Archbishop Makarios IIIen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countryRomaniaen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.15386/cjmed-518en_US
dc.identifier.pmid26733748-
dc.relation.issue4en_US
dc.relation.volume88en_US
cut.common.academicyear2014-2015en_US
dc.identifier.spage494en_US
dc.identifier.epage499en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextWith Fulltext-
item.openairetypearticle-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-2906-5743-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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