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Title: A spheroidal control volume for the quantitative measurement of regurgitant flow by cardiac MRI
Authors: Kortright, Eduardo 
Rayarao, Geetha 
Li, Longchuan 
Anayiotos, Andreas 
Biederman, Robert W.W. 
Doyle, Mark 
Major Field of Science: Engineering and Technology
Field Category: Medical Engineering
Keywords: Magnetic resonance imaging;Heart valves--Diseases;Apparitions;Image processing
Issue Date: 2008
Source: Technology and Health Care, 2008, vol. 16, iss. 1, pp. 31-45
Volume: 16
Issue: 1
Start page: 31
End page: 45
Journal: Technology and Health Care 
Abstract: Purpose: We sought to show that a spheroidally shaped control volume (CV), formed from a minimal MRI data set, can be used to measure regurgitant flow through a defective cardiac valve consistently and accurately under a variety of flow conditions. Materials and Methods: Using a pulsatile flow pump and phantoms simulating severe valvular regurgitation, we acquired 31 scans of two or three radially oriented slices, using a variety of flow waveforms and regurgitant volumes of 12 to 55 ml. Data sets included high- and low-resolution scans, and variable-rate sparse sampling was also applied to reduce the scan time. An oblate spheroid was placed in the pump chamber opposite the jet and fit as tightly as possible to isomagnitude velocity contours at 25% of the velocity encoding limit. Results: Normalized regurgitant volumes (NRVs) expressed as a percentage of the pump setting were obtained from the product of the spheroid surface area with the velocities normal to it. Mean ± SD NRV values were 96.8 ± 6.6% for all scans. Imaging times in the breath-hold range were obtained using reduced resolution and variable-rate sparse sampling approaches without significant degradation in accuracy. Conclusion: In our preliminary findings, the spheroidal CV method showed clear potential for the development of a robust, clinically feasible technique for the measurement of regurgitant volume.
ISSN: 1878-7401
DOI: 10.3233/THC-2008-16104
Rights: © IOS
Type: Article
Affiliation : Allegheny General Hospital 
University of Alabama 
Cyprus University of Technology 
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