Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/30764
Title: Characterization of the internal working-life exposome using minimally and non-invasive sampling methods - a narrative review
Authors: Verscheure, Eline 
Stierum, Rob 
Schlünssen, Vivi 
Lund Würtz, Anne Mette 
Vanneste, Dorian 
Kogevinas, Manolis 
Harding, Barbara N 
Broberg, Karin 
Narui, Shan Zienolddiny 
Erdem, Johanna Samulin 
Das, Mrinal K 
Makris, Konstantinos C. 
Konstantinou, Corina 
Andrianou, Xanthi 
Dekkers, Susan 
Morris, Lorna 
Pronk, Anjoeka 
Godderis, Lode 
Ghosh, Manosij 
Major Field of Science: Medical and Health Sciences
Field Category: MEDICAL AND HEALTH SCIENCES;Health Sciences
Keywords: Biomarker;Biomonitoring;Data availability;Exposome;Non-invasive sampling;Occupational;Self-sampling
Issue Date: 1-Dec-2023
Source: Environmental Research, 2023, vol. 238
Volume: 238
Journal: Environmental Research 
Abstract: During recent years, we are moving away from the 'one exposure, one disease'-approach in occupational settings and towards a more comprehensive approach, taking into account the totality of exposures during a life course by using an exposome approach. Taking an exposome approach however is accompanied by many challenges, one of which, for example, relates to the collection of biological samples. Methods used for sample collection in occupational exposome studies should ideally be minimally invasive, while at the same time sensitive, and enable meaningful repeated sampling in a large population and over a longer time period. This might be hampered in specific situations e.g., people working in remote areas, during pandemics or with flexible work hours. In these situations, using self-sampling techniques might offer a solution. Therefore, our aim was to identify existing self-sampling techniques and to evaluate the applicability of these techniques in an occupational exposome context by conducting a literature review. We here present an overview of current self-sampling methodologies used to characterize the internal exposome. In addition, the use of different biological matrices was evaluated and subdivided based on their level of invasiveness and applicability in an occupational exposome context. In conclusion, this review and the overview of self-sampling techniques presented herein can serve as a guide in the design of future (occupational) exposome studies while circumventing sample collection challenges associated with exposome studies.
URI: https://hdl.handle.net/20.500.14279/30764
ISSN: 00139351
DOI: 10.1016/j.envres.2023.117001
Rights: © The Authors
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation : Katholieke Universiteit Leuven 
The Netherlands Organisation for Applied Scientific Research TNO 
Aarhus University 
ISGlobal 
Lund University 
Karolinska Institutet 
National Institute for Occupational Safety and Health 
Cyprus University of Technology 
LifeGlimmer GmbH 
Idewe 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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