Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/27024
Title: An exposome-wide association study on body mass index in adolescents using the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2013-2014 data
Authors: Haddad, Nadine 
Andrianou, Xanthi 
Parrish, Christa 
Oikonomou, Stavros 
Makris, Konstantinos C. 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Keywords: Adolescent;Biomarkers;Body Mass Index;Environmental Exposure;Exposome;Humans;Nutrition Surveys
Issue Date: 25-May-2022
Source: Scientific Reports, vol. 12, articl. no 8856
Volume: 12
Journal: Scientific Reports 
Abstract: Excess weight is a public health challenge affecting millions worldwide, including younger age groups. The human exposome concept presents a novel opportunity to comprehensively characterize all non-genetic disease determinants at susceptible time windows. This study aimed to describe the association between multiple lifestyle and clinical exposures and body mass index (BMI) in adolescents using the exposome framework. We conducted an exposome-wide association (ExWAS) study using U.S. National Health and Nutrition Examination Survey (NHANES) 2003-2004 wave for discovery of associations between study population characteristics and zBMI, and used the 2013-2014 wave to replicate analysis. We included non-diabetic and non-pregnant adolescents aged 12-18 years. We performed univariable and multivariable linear regression analysis adjusted for age, sex, race/ethnicity, household smoking, and income to poverty ratio, and corrected for false-discovery rate (FDR). A total of 1899 and 1224 participants were eligible from 2003-2004 and 2013-2014 survey waves. Weighted proportions of overweight were 18.4% and 18.5% whereas those for obese were 18.1% and 20.6% in 2003-2004 and 2013-2014, respectively. Retained exposure agents included 75 laboratory (clinical and biomarkers of environmental chemical exposures) and 64 lifestyle (63 dietary and 1 physical activity) variables. After FDR correction, univariable regression identified 27 and 12 predictors in discovery and replication datasets, respectively, while multivariable regression identified 22 and 9 predictors in discovery and replication datasets, respectively. Six were significant in both datasets: alanine aminotransferase, gamma glutamyl transferase, segmented neutrophils number, triglycerides; uric acid and white blood cell count. In this ExWAS study using NHANES data, we described associations between zBMI, nutritional, clinical and environmental factors in adolescents. Future studies are warranted to investigate the role of the identified predictors as early-stage biomarkers of increased BMI and associated pathologies among adolescents and to replicate findings to other populations.
URI: https://hdl.handle.net/20.500.14279/27024
ISSN: 20452322
DOI: 10.1038/s41598-022-12459-z
Rights: This article is licensed under a Creative Commons Attribution 4.0 International License
Type: Article
Affiliation : Cyprus University of Technology 
Water and Health Lab 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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