Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/23922
Title: Gamma Oscillations in Alzheimer’s Disease and Their Potential Therapeutic Role
Authors: Traikapi, Artemis 
Konstantinou, Nikos 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: Alzheimer’s disease;Gamma brain oscillations;Sensory stimuli;Auditory and visual stimulation;40 Hz brain stimulation
Issue Date: 13-Dec-2021
Source: Frontiers in Systems Neuroscience, 2021, vol. 15, articl. no. 782399
Volume: 15
Journal: Frontiers in Systems Neuroscience 
Abstract: Despite decades of research, Alzheimer’s Disease (AD) remains a lethal neurodegenerative disorder for which there are no effective treatments. This review examines the latest evidence of a novel and newly introduced perspective, which focuses on the restoration of gamma oscillations and investigates their potential role in the treatment of AD. Gamma brain activity (∼25–100 Hz) has been well-known for its role in cognitive function, including memory, and it is fundamental for healthy brain activity and intra-brain communication. Aberrant gamma oscillations have been observed in both mice AD models and human AD patients. A recent line of work demonstrated that gamma entrainment, through auditory and visual sensory stimulation, can effectively attenuate AD pathology and improve cognitive function in mice models of the disease. The first evidence from AD patients indicate that gamma entrainment therapy can reduce loss of functional connectivity and brain atrophy, improve cognitive function, and ameliorate several pathological markers of the disease. Even though research is still in its infancy, evidence suggests that gamma-based therapy may have a disease-modifying effect and has signified a new and promising era in AD research.
URI: https://hdl.handle.net/20.500.14279/23922
ISSN: 16625137
DOI: 10.3389/fnsys.2021.782399
Rights: © The Author(s).
Type: Article
Affiliation : Cyprus University of Technology 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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