Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/23922
DC FieldValueLanguage
dc.contributor.authorTraikapi, Artemis-
dc.contributor.authorKonstantinou, Nikos-
dc.date.accessioned2022-02-11T07:34:07Z-
dc.date.available2022-02-11T07:34:07Z-
dc.date.issued2021-12-13-
dc.identifier.citationFrontiers in Systems Neuroscience, 2021, vol. 15, articl. no. 782399en_US
dc.identifier.issn16625137-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/23922-
dc.description.abstractDespite decades of research, Alzheimer’s Disease (AD) remains a lethal neurodegenerative disorder for which there are no effective treatments. This review examines the latest evidence of a novel and newly introduced perspective, which focuses on the restoration of gamma oscillations and investigates their potential role in the treatment of AD. Gamma brain activity (∼25–100 Hz) has been well-known for its role in cognitive function, including memory, and it is fundamental for healthy brain activity and intra-brain communication. Aberrant gamma oscillations have been observed in both mice AD models and human AD patients. A recent line of work demonstrated that gamma entrainment, through auditory and visual sensory stimulation, can effectively attenuate AD pathology and improve cognitive function in mice models of the disease. The first evidence from AD patients indicate that gamma entrainment therapy can reduce loss of functional connectivity and brain atrophy, improve cognitive function, and ameliorate several pathological markers of the disease. Even though research is still in its infancy, evidence suggests that gamma-based therapy may have a disease-modifying effect and has signified a new and promising era in AD research.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofFrontiers in Systems Neuroscienceen_US
dc.rights© The Author(s).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlzheimer’s diseaseen_US
dc.subjectGamma brain oscillationsen_US
dc.subjectSensory stimulien_US
dc.subjectAuditory and visual stimulationen_US
dc.subject40 Hz brain stimulationen_US
dc.titleGamma Oscillations in Alzheimer’s Disease and Their Potential Therapeutic Roleen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.3389/fnsys.2021.782399en_US
dc.identifier.pmid34966263-
dc.identifier.scopus2-s2.0-85121670525-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85121670525-
dc.relation.volume15en_US
cut.common.academicyear2021-2022en_US
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.journal.journalissn1662-5137-
crisitem.journal.publisherFrontiers-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0003-4531-3636-
crisitem.author.parentorgFaculty of Health Sciences-
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