Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/23789
Title: Aerobic oxidations in flow: Opportunities for the fine chemicals and pharmaceuticals industries
Authors: Gavriilidis, Asterios 
Constantinou, Achilleas 
Hellgardt, Klaus 
Hii, King Kuok Mimi 
Hutchings, Graham J. 
Brett, Gemma L. 
Kuhn, Simon 
Marsden, Stephen P. 
Major Field of Science: Natural Sciences
Field Category: Chemical Sciences
Keywords: Molecular oxygen;Aerobic oxidation reactions;Oxidation reactions;Pharmaceuticals
Issue Date: 1-Dec-2016
Source: Reaction Chemistry & Engineering, 2021, vol. 1, no. 6, pp. 595–612
Volume: 1
Issue: 6
Start page: 595
End page: 612
Journal: Reaction Chemistry & Engineering 
Abstract: Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but not least, further challenges and future perspectives are presented in the concluding remarks.
URI: https://hdl.handle.net/20.500.14279/23789
ISSN: 20589883
DOI: 10.1039/c6re00155f
Rights: This article is licensed under a Creative Commons Attribution
Type: Article
Affiliation : University College London 
Imperial College London 
Cardiff University 
KU Leuven 
University of Leeds 
London South Bank University 
Appears in Collections:Άρθρα/Articles

Files in This Item:
File Description SizeFormat
c6re00155f.pdfFulltext1.73 MBAdobe PDFView/Open
CORE Recommender
Show full item record

SCOPUSTM   
Citations

143
checked on Mar 14, 2024

WEB OF SCIENCETM
Citations

128
Last Week
0
Last month
7
checked on Oct 29, 2023

Page view(s)

238
Last Week
2
Last month
14
checked on Jun 18, 2024

Download(s) 20

132
checked on Jun 18, 2024

Google ScholarTM

Check

Altmetric


Items in KTISIS are protected by copyright, with all rights reserved, unless otherwise indicated.