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https://hdl.handle.net/20.500.14279/22937
Τίτλος: | p-cymene impairs SARS-CoV-2 and Influenza A (H1N1) viral replication: In silico predicted interaction with SARS-CoV-2 nucleocapsid protein and H1N1 nucleoprotein | Συγγραφείς: | Panagiotopoulos, Athanasios Tseliou, Melpomeni Karakasiliotis, Ioannis Kotzampasi, Danai Maria Daskalakis, Vangelis Kesesidis, Nikolaos Notas, George Lionis, Christos D. Kampa, Marilena Pirintsos, Stergios Sourvinos, George Castanas, Elias |
Major Field of Science: | Natural Sciences | Field Category: | Biological Sciences | Λέξεις-κλειδιά: | Ebola;SARS-CoV-2;Importin A;Influenza A;Nucleocapsid protein;Nucleoprotein;p-cymene;Rabies | Ημερομηνία Έκδοσης: | Αυγ-2021 | Πηγή: | Pharmacology Research & Perspectives, 2021, vol. 9, no. 4, articl. no. e00798 | Volume: | 9 | Issue: | 4 | Περιοδικό: | Pharmacology Research & Perspectives | Περίληψη: | Therapeutic regimens for the COVID-19 pandemics remain unmet. In this line, repurposing of existing drugs against known or predicted SARS-CoV-2 protein actions have been advanced, while natural products have also been tested. Here, we propose that p-cymene, a natural monoterpene, can act as a potential novel agent for the treatment of SARS-CoV-2-induced COVID-19 and other RNA-virus-induced diseases (influenza, rabies, Ebola). We show by extensive molecular simulations that SARS-CoV-2 C-terminal structured domain contains a nuclear localization signal (NLS), like SARS-CoV, on which p-cymene binds with low micromolar affinity, impairing nuclear translocation of this protein and inhibiting viral replication, as verified by preliminary in vitro experiments. A similar mechanism may occur in other RNA-viruses (influenza, rabies and Ebola), also verified in vitro for influenza, by interaction of p-cymene with viral nucleoproteins, and structural modification of their NLS site, weakening its interaction with importin A. This common mechanism of action renders therefore p-cymene as a possible antiviral, alone, or in combination with other agents, in a broad spectrum of RNA viruses, from SARS-CoV-2 to influenza A infections. | URI: | https://hdl.handle.net/20.500.14279/22937 | ISSN: | 20521707 | DOI: | 10.1002/prp2.798 | Rights: | © The Authors. This is an open access article under the terms of the Creative Commons Attribution- NonCommercial- NoDerivs License. Attribution-NonCommercial-NoDerivatives 4.0 International |
Type: | Article | Affiliation: | University of Crete Democritus University of Thrace Cyprus University of Technology Nature Crete Pharmaceuticals |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
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