Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/19540
Title: | Human Leukocyte Antigen (HLA) Influence on Prognosis of Autoimmune Hearing Loss | Authors: | Psillas, George K. Binos, Paris Dimas, Grigorios G Daniilidis, Michalis Constantinidis, Jiannis |
Major Field of Science: | Medical and Health Sciences | Field Category: | Health Sciences | Keywords: | Hearing loss;HLA antigens;Autoantibodies;Autoimmunity | Issue Date: | 25-Jan-2021 | Source: | Audiology Research, 2021, vol. 11, no. 1, pp. 31-37 | Volume: | 11 | Issue: | 1 | Start page: | 31 | End page: | 37 | Journal: | Audiology Research | Abstract: | Background: To evaluate the effect of human leukocyte antigen (HLA) on hearing outcome in patients suffering from autoimmune hearing loss (AIHL). Materials and Methods: The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden, fluctuating, or quickly progressing (<12 months) sensorineural hearing loss (uni-/bilateral). The molecular typing of HLA alleles was achieved by using polymerase chain reaction procedures. Patients underwent a tapering schema of steroid treatment and audiometric features were recorded. A logistic regression model was used to identify which HLA typing alleles were statistically significant in patients’ response to treatment. Results: Forty patients with AIHL were found to be carriers of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles. No statistically significant influence of HLA B27, B35, B51, C4, C7, DRB1*04 HLA alleles typing was detected for the prognosis of AIHL. In these patients, the onset of AIHL was mainly progressive (53.8%), 29.2% of them had moderate hearing loss, and most of the cases had both bilateral hearing loss (62.5%) and downsloping audiogram (40%). Conclusion: The presence of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles had no significant effect on a favorable outcome of AIHL. However, larger samples of patients are necessary in order to improve the knowledge about the HLA influence on the clinical course of AIHL. | URI: | https://hdl.handle.net/20.500.14279/19540 | ISSN: | 20394330 | DOI: | 10.3390/audiolres11010004 | Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Type: | Article | Affiliation : | Aristotle University of Thessaloniki Cyprus University of Technology |
Publication Type: | Peer Reviewed |
Appears in Collections: | Άρθρα/Articles |
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