Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/19540
Title: Human Leukocyte Antigen (HLA) Influence on Prognosis of Autoimmune Hearing Loss
Authors: Psillas, George K. 
Binos, Paris 
Dimas, Grigorios G 
Daniilidis, Michalis 
Constantinidis, Jiannis 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Keywords: Hearing loss;HLA antigens;Autoantibodies;Autoimmunity
Issue Date: 25-Jan-2021
Source: Audiology Research, 2021, vol. 11, no. 1, pp. 31-37
Volume: 11
Issue: 1
Start page: 31
End page: 37
Journal: Audiology Research 
Abstract: Background: To evaluate the effect of human leukocyte antigen (HLA) on hearing outcome in patients suffering from autoimmune hearing loss (AIHL). Materials and Methods: The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden, fluctuating, or quickly progressing (<12 months) sensorineural hearing loss (uni-/bilateral). The molecular typing of HLA alleles was achieved by using polymerase chain reaction procedures. Patients underwent a tapering schema of steroid treatment and audiometric features were recorded. A logistic regression model was used to identify which HLA typing alleles were statistically significant in patients’ response to treatment. Results: Forty patients with AIHL were found to be carriers of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles. No statistically significant influence of HLA B27, B35, B51, C4, C7, DRB1*04 HLA alleles typing was detected for the prognosis of AIHL. In these patients, the onset of AIHL was mainly progressive (53.8%), 29.2% of them had moderate hearing loss, and most of the cases had both bilateral hearing loss (62.5%) and downsloping audiogram (40%). Conclusion: The presence of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles had no significant effect on a favorable outcome of AIHL. However, larger samples of patients are necessary in order to improve the knowledge about the HLA influence on the clinical course of AIHL.
URI: https://hdl.handle.net/20.500.14279/19540
ISSN: 20394330
DOI: 10.3390/audiolres11010004
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Type: Article
Affiliation : Aristotle University of Thessaloniki 
Cyprus University of Technology 
Publication Type: Peer Reviewed
Appears in Collections:Άρθρα/Articles

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