Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/19540
DC FieldValueLanguage
dc.contributor.authorPsillas, George K.-
dc.contributor.authorBinos, Paris-
dc.contributor.authorDimas, Grigorios G-
dc.contributor.authorDaniilidis, Michalis-
dc.contributor.authorConstantinidis, Jiannis-
dc.date.accessioned2021-02-08T11:26:19Z-
dc.date.available2021-02-08T11:26:19Z-
dc.date.issued2021-01-25-
dc.identifier.citationAudiology Research, 2021, vol. 11, no. 1, pp. 31-37en_US
dc.identifier.issn20394330-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/19540-
dc.description.abstractBackground: To evaluate the effect of human leukocyte antigen (HLA) on hearing outcome in patients suffering from autoimmune hearing loss (AIHL). Materials and Methods: The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden, fluctuating, or quickly progressing (<12 months) sensorineural hearing loss (uni-/bilateral). The molecular typing of HLA alleles was achieved by using polymerase chain reaction procedures. Patients underwent a tapering schema of steroid treatment and audiometric features were recorded. A logistic regression model was used to identify which HLA typing alleles were statistically significant in patients’ response to treatment. Results: Forty patients with AIHL were found to be carriers of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles. No statistically significant influence of HLA B27, B35, B51, C4, C7, DRB1*04 HLA alleles typing was detected for the prognosis of AIHL. In these patients, the onset of AIHL was mainly progressive (53.8%), 29.2% of them had moderate hearing loss, and most of the cases had both bilateral hearing loss (62.5%) and downsloping audiogram (40%). Conclusion: The presence of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles had no significant effect on a favorable outcome of AIHL. However, larger samples of patients are necessary in order to improve the knowledge about the HLA influence on the clinical course of AIHL.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofAudiology Researchen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectHearing lossen_US
dc.subjectHLA antigensen_US
dc.subjectAutoantibodiesen_US
dc.subjectAutoimmunityen_US
dc.titleHuman Leukocyte Antigen (HLA) Influence on Prognosis of Autoimmune Hearing Lossen_US
dc.typeArticleen_US
dc.collaborationAristotle University of Thessalonikien_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryHealth Sciencesen_US
dc.journalsOpen Accessen_US
dc.countryGreeceen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.3390/audiolres11010004en_US
dc.identifier.pmid33503870-
dc.relation.issue1en_US
dc.relation.volume11en_US
cut.common.academicyear2020-2021en_US
dc.identifier.spage31en_US
dc.identifier.epage37en_US
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairetypearticle-
item.cerifentitytypePublications-
crisitem.journal.journalissn2039-4349-
crisitem.journal.publisherMDPI-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0003-3850-1866-
crisitem.author.parentorgFaculty of Health Sciences-
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