Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14279/19540
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Psillas, George K. | - |
dc.contributor.author | Binos, Paris | - |
dc.contributor.author | Dimas, Grigorios G | - |
dc.contributor.author | Daniilidis, Michalis | - |
dc.contributor.author | Constantinidis, Jiannis | - |
dc.date.accessioned | 2021-02-08T11:26:19Z | - |
dc.date.available | 2021-02-08T11:26:19Z | - |
dc.date.issued | 2021-01-25 | - |
dc.identifier.citation | Audiology Research, 2021, vol. 11, no. 1, pp. 31-37 | en_US |
dc.identifier.issn | 20394330 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14279/19540 | - |
dc.description.abstract | Background: To evaluate the effect of human leukocyte antigen (HLA) on hearing outcome in patients suffering from autoimmune hearing loss (AIHL). Materials and Methods: The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden, fluctuating, or quickly progressing (<12 months) sensorineural hearing loss (uni-/bilateral). The molecular typing of HLA alleles was achieved by using polymerase chain reaction procedures. Patients underwent a tapering schema of steroid treatment and audiometric features were recorded. A logistic regression model was used to identify which HLA typing alleles were statistically significant in patients’ response to treatment. Results: Forty patients with AIHL were found to be carriers of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles. No statistically significant influence of HLA B27, B35, B51, C4, C7, DRB1*04 HLA alleles typing was detected for the prognosis of AIHL. In these patients, the onset of AIHL was mainly progressive (53.8%), 29.2% of them had moderate hearing loss, and most of the cases had both bilateral hearing loss (62.5%) and downsloping audiogram (40%). Conclusion: The presence of HLA B27, B35, B51, C4, C7, and DRB1*04 alleles had no significant effect on a favorable outcome of AIHL. However, larger samples of patients are necessary in order to improve the knowledge about the HLA influence on the clinical course of AIHL. | en_US |
dc.format | en_US | |
dc.language.iso | en | en_US |
dc.relation.ispartof | Audiology Research | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | en_US |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | Hearing loss | en_US |
dc.subject | HLA antigens | en_US |
dc.subject | Autoantibodies | en_US |
dc.subject | Autoimmunity | en_US |
dc.title | Human Leukocyte Antigen (HLA) Influence on Prognosis of Autoimmune Hearing Loss | en_US |
dc.type | Article | en_US |
dc.collaboration | Aristotle University of Thessaloniki | en_US |
dc.collaboration | Cyprus University of Technology | en_US |
dc.subject.category | Health Sciences | en_US |
dc.journals | Open Access | en_US |
dc.country | Greece | en_US |
dc.country | Cyprus | en_US |
dc.subject.field | Medical and Health Sciences | en_US |
dc.publication | Peer Reviewed | en_US |
dc.identifier.doi | 10.3390/audiolres11010004 | en_US |
dc.identifier.pmid | 33503870 | - |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 11 | en_US |
cut.common.academicyear | 2020-2021 | en_US |
dc.identifier.spage | 31 | en_US |
dc.identifier.epage | 37 | en_US |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.journal.journalissn | 2039-4349 | - |
crisitem.journal.publisher | MDPI | - |
crisitem.author.dept | Department of Rehabilitation Sciences | - |
crisitem.author.faculty | Faculty of Health Sciences | - |
crisitem.author.orcid | 0000-0003-3850-1866 | - |
crisitem.author.parentorg | Faculty of Health Sciences | - |
Appears in Collections: | Άρθρα/Articles |
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audiolres-11-00004.pdf | 246.73 kB | Adobe PDF | View/Open |
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