Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο:
https://hdl.handle.net/20.500.14279/1942
Τίτλος: | Expression of Fas (CD95) and Fas ligand on peripheral blood mononuclear cells in critical illness and association with multiorgan dysfunction severity and survival | Συγγραφείς: | Papathanassoglou, Elizabeth Moynihan, Jan McDermott, Michael |
Major Field of Science: | Medical and Health Sciences | Field Category: | MEDICAL AND HEALTH SCIENCES | Λέξεις-κλειδιά: | Critical care medicine;Catastrophic illness;Apoptosis;Cytokines;Multiple organ failure;Nitric oxide;T cells;Tumor necrosis factor;Cell death | Ημερομηνία Έκδοσης: | Απρ-2001 | Πηγή: | Critical care medicine, 2001, vol. 29, no. 4, pp. 709-718 | Volume: | 29 | Issue: | 4 | Start page: | 709 | End page: | 718 | Περιοδικό: | Critical Care Medicine | Περίληψη: | Objective: This was an exploratory study with three goals: a) to quantify the expression of the apoptotic receptor Fas and its ligand (FasL) on peripheral blood mononuclear cells (PBMCs) in patients with, or at risk for, multiple organ dysfunction syndrome (MODS); b) to compare this expression with the respective expression in matched controls; and c) to explore the association with MODS severity and survival. Design: Repeated-measures correlational and cross-sectional design. Setting: The surgical, medical, and the trauma/burn intensive care unit of an academic institution. Patients: Thirty-five adult, critically ill patients meeting the diagnostic criteria for systemic inflammatory response syndrome (SIRS) with MODS, or at risk for MODS, were followed for 14 days. Thirty-five non-SIRS controls matched with patients for age, gender, and race comprised the control group. Interventions: Peripheral blood sampling every 48 hrs. Measurements/Main Results: T cells were considerably depleted in SIRS/MODS patients (p < .001), and Fas and FasL expression on PBMCs (flow cytometric analysis) was elevated significantly compared with controls (p < .001). In contrast to controls, non-T cells were the major sources of Fas and FasL in SIRS/MODS patients (p < .01). Expression of Fas and FasL exhibited a bimodal correlation with severity (p < .03). High severity patients demonstrated increasing Fas and FasL expression with increasing severity in contrast to declining expression in moderately severe patients. Fas and FasL measurements were significantly and positively associated with the likelihood of survival (p < .05). Conclusions: Dysregulation in the expression of apoptotic receptors Fas and FasL, at least in PBMCs, may be involved in the pathophysiology of SIRS, the related lymphocytopenia, and the onset of MODS and the related morbidity and mortality rates | URI: | https://hdl.handle.net/20.500.14279/1942 | ISSN: | 15300293 | DOI: | 10.1097/00003246-200104000-00002 | Rights: | © Lippincott Williams & Wilkins | Type: | Article | Affiliation: | National and Kapodistrian University of Athens | Publication Type: | Peer Reviewed |
Εμφανίζεται στις συλλογές: | Άρθρα/Articles |
CORE Recommender
SCOPUSTM
Citations
59
checked on 9 Νοε 2023
WEB OF SCIENCETM
Citations
50
Last Week
0
0
Last month
0
0
checked on 29 Οκτ 2023
Page view(s)
505
Last Week
0
0
Last month
35
35
checked on 13 Μαρ 2025
Google ScholarTM
Check
Altmetric
Όλα τα τεκμήρια του δικτυακού τόπου προστατεύονται από πνευματικά δικαιώματα