Please use this identifier to cite or link to this item:
Title: Sideritis perfoliata (subsp. perfoliata) nutritive value and its potential medicinal properties
Authors: Lall, Namrita 
Chrysargyris, Antonios 
Lambrechts, Isa 
Fibrich, Bianca 
Staden, Analike Blom Van 
Twilley, Danielle 
Canha, Marco Nuno de 
Oosthuizen, Carel Basson 
Bodiba, Dikonketso 
Tzortzakis, Nikos G. 
Major Field of Science: Natural Sciences
Field Category: Chemical Sciences
Keywords: Cutibacterium acnes;Sideritis perfoliata;Antimycobacterial;Antioxidant capacity;Melanin inhibition;Wrinkles
Issue Date: Nov-2019
Source: Antioxidants, 2019, vol. 8, no. 11, articl. no. 521
Volume: 8
Issue: 11
Journal: Antioxidants 
Abstract: Sideritis perfoliata L. subsp. perfoliata is an endemic species of the Eastern Mediterranean region with several uses in traditional medicine. The present study aims to explore the unknown properties of S. perfoliata investigating the nutritional content as well as the antioxidant, anticancer, antituberculosis, antiwrinkle, anti-acne, hvper/hvpo-pigmentation and antibacterial activities. Mineral content, nutritional value, the composition and antioxidant properties of the essential oil, the antitvrosinase, the antibacterial activity and anti-elastase potential of the extract, were evaluated. The antiproliferative activity of S. perfoliata against cervical cancer (HeLa), human melanoma (UCT-Mel-1), human hepatocellular carcinoma (HepG2) and human epidermoid carcinoma (A431) was investigated. Cytotoxic effects on normal human keratinocyte (HaCat) and kidney epithelial (Vero) cell lines were also determined. Sideritis perfoliata exhibited high nutritional value of proteins and minerals (K, P, Mg, Fe, Zn, Cu). The most abundant components of the essential oil were found to be a-pinene, |3-phelladrene, valeranone, |3-pinene and sabinene. The ethanolic extract of S. perfoliata dis moderate antioxidant potential and antibacterial activity against Prevotella intermedia. Noteworthy elastase and moderate anticancer potential against the human liver cancer cell line (He observed with|lC5o|vaIues of 57.18 ±|3.22 ug/mL and 64.27 ±|2.04 ug/mL respectively. The noteworthy in vitro activity of S. perfoliata could be due to the presence of flavonoids and phenols in the leaves, having high nutritional value. Sideritis perfoliata could potentially be useful to reduce the appearance of wrinkles and for the treatment of liver cancer. The moderate antibacterial, antioxidant and elastase lant can be linked to the traditional use of S. verfoliata for the treatment of wounds and inflammation.
ISSN: 2076-3921
DOI: 10.3390/antiox8110521
Rights: © by the authors.
Type: Article
Affiliation : University of Pretoria 
University of Missouri 
JSS Academy of Higher Education and Research 
Cyprus University of Technology 
Appears in Collections:Άρθρα/Articles

Files in This Item:
File Description SizeFormat
antioxidants-08-00521.pdfFulltext459.1 kBAdobe PDFView/Open
CORE Recommender
Show full item record

Citations 50

checked on Nov 9, 2023


Last Week
Last month
checked on Oct 29, 2023

Page view(s) 50

Last Week
Last month
checked on Dec 2, 2023

Download(s) 50

checked on Dec 2, 2023

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons