Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/18547
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dc.contributor.authorLall, Namrita-
dc.contributor.authorChrysargyris, Antonios-
dc.contributor.authorLambrechts, Isa-
dc.contributor.authorFibrich, Bianca-
dc.contributor.authorStaden, Analike Blom Van-
dc.contributor.authorTwilley, Danielle-
dc.contributor.authorCanha, Marco Nuno de-
dc.contributor.authorOosthuizen, Carel Basson-
dc.contributor.authorBodiba, Dikonketso-
dc.contributor.authorTzortzakis, Nikos G.-
dc.date.accessioned2020-07-22T11:36:11Z-
dc.date.available2020-07-22T11:36:11Z-
dc.date.issued2019-11-
dc.identifier.citationAntioxidants, 2019, vol. 8, no. 11, articl. no. 521en_US
dc.identifier.issn2076-3921-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/18547-
dc.description.abstractSideritis perfoliata L. subsp. perfoliata is an endemic species of the Eastern Mediterranean region with several uses in traditional medicine. The present study aims to explore the unknown properties of S. perfoliata investigating the nutritional content as well as the antioxidant, anticancer, antituberculosis, antiwrinkle, anti-acne, hvper/hvpo-pigmentation and antibacterial activities. Mineral content, nutritional value, the composition and antioxidant properties of the essential oil, the antitvrosinase, the antibacterial activity and anti-elastase potential of the extract, were evaluated. The antiproliferative activity of S. perfoliata against cervical cancer (HeLa), human melanoma (UCT-Mel-1), human hepatocellular carcinoma (HepG2) and human epidermoid carcinoma (A431) was investigated. Cytotoxic effects on normal human keratinocyte (HaCat) and kidney epithelial (Vero) cell lines were also determined. Sideritis perfoliata exhibited high nutritional value of proteins and minerals (K, P, Mg, Fe, Zn, Cu). The most abundant components of the essential oil were found to be a-pinene, |3-phelladrene, valeranone, |3-pinene and sabinene. The ethanolic extract of S. perfoliata dis moderate antioxidant potential and antibacterial activity against Prevotella intermedia. Noteworthy elastase and moderate anticancer potential against the human liver cancer cell line (He observed with|lC5o|vaIues of 57.18 ±|3.22 ug/mL and 64.27 ±|2.04 ug/mL respectively. The noteworthy in vitro activity of S. perfoliata could be due to the presence of flavonoids and phenols in the leaves, having high nutritional value. Sideritis perfoliata could potentially be useful to reduce the appearance of wrinkles and for the treatment of liver cancer. The moderate antibacterial, antioxidant and elastase lant can be linked to the traditional use of S. verfoliata for the treatment of wounds and inflammation.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofAntioxidantsen_US
dc.rights© by the authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCutibacterium acnesen_US
dc.subjectSideritis perfoliataen_US
dc.subjectAntimycobacterialen_US
dc.subjectAntioxidant capacityen_US
dc.subjectMelanin inhibitionen_US
dc.subjectWrinklesen_US
dc.titleSideritis perfoliata (subsp. perfoliata) nutritive value and its potential medicinal propertiesen_US
dc.typeArticleen_US
dc.collaborationUniversity of Pretoriaen_US
dc.collaborationUniversity of Missourien_US
dc.collaborationJSS Academy of Higher Education and Researchen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryChemical Sciencesen_US
dc.journalsOpen Accessen_US
dc.countrySouth Africaen_US
dc.countryUnited Statesen_US
dc.countryIndiaen_US
dc.countryCyprusen_US
dc.subject.fieldNatural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.3390/antiox8110521en_US
dc.relation.issue11en_US
dc.relation.volume8en_US
cut.common.academicyear2019-2020en_US
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.grantfulltextopen-
crisitem.journal.journalissn2076-3921-
crisitem.journal.publisherMDPI-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0002-1067-7977-
crisitem.author.orcid0000-0002-2719-6627-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
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