Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14279/18524
DC FieldValueLanguage
dc.contributor.authorHaddad, Nadine-
dc.contributor.authorAndrianou, Xanthi-
dc.contributor.authorMakris, Konstantinos C.-
dc.date.accessioned2020-07-21T06:15:03Z-
dc.date.available2020-07-21T06:15:03Z-
dc.date.issued2019-12-
dc.identifier.citationCurrent Pollution Reports, vol. 5, no. 4, pp. 378–393en_US
dc.identifier.issn21986592-
dc.identifier.urihttps://hdl.handle.net/20.500.14279/18524-
dc.description.abstractEmbraced as a breaking through methodological framework, the exposome is accompanied by novel exposure assessment methods and data processing tools or models. However, systematic mapping of the landscape of exposome studies, including their characteristics, components, tools and language has not been done so far. We conducted a scoping review to answer the question: “Which main domains of the human exposome have been included in the literature and which metrics of exposure(s)/outcome(s) have been used?” We performed a comprehensive search of human studies containing the word “exposom*” and published up to March 8, 2019. We screened 1133 records and 82 studies were included in the analysis. Most studies took place in Europe. Data analysis showed the non-systematic use of the exposome term. Most studies had a longitudinal design (n = 30, 37%), were conducted on adults (n = 40, 51%), and had a clearly defined health outcome in methodology (n = 48, 61%). Omics tools, such as metabolomics were used in 38 studies (49%), while environment-wide association analysis was used in 9 studies (11%). Thirty-seven (48%) studies included all three exposome domains (general external, specific external and internal) while 33 (42%) studies included two. Despite the large number of environmental components that comprise each of the exposome domains, only a subset has been currently studied. An optimized consideration of the components from all exposome domains, as well as the standardization of the exposure and outcome assessment methods is warranted to advance the utility of the human exposome concept.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Pollution Reportsen_US
dc.rights© 2019, The Author(s).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCohortsen_US
dc.subjectExposomeen_US
dc.subjectDomainsen_US
dc.subjectEWASen_US
dc.subjectOmicsen_US
dc.subjectEnvironmental healthen_US
dc.subjectPersonalized medicineen_US
dc.subjectTrialsen_US
dc.titleA Scoping Review on the Characteristics of Human Exposome Studiesen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryHealth Sciencesen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1007/s40726-019-00130-7en_US
dc.identifier.scopus2-s2.0-85076112090-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85076112090-
dc.relation.issue4en_US
dc.relation.volume5en_US
cut.common.academicyear2019-2020en_US
dc.identifier.spage378en_US
dc.identifier.epage393en_US
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypearticle-
crisitem.journal.journalissn2198-6592-
crisitem.journal.publisherSpringer Nature-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptDepartment of Rehabilitation Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-2906-5743-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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